Journal of Developmental Medicine(Electronic Version)  2015, Vol. 3 Issue (4): 241-245 DOI: |
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| Propylthioouracil-associated antineutrophil cytoplasmic antibody-positive vasculitis: 1 case report and review of literature |
| SHI Zhuo,SUN Tao,XIA Zheng-kun
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| SHI Zhuo,SUN Tao,XIA Zheng-kun(Department of Pediatrics, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China) |
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Abstract Objective To analyze pathogenesis of antineutrophil cytoplasmic antibody-positive vasculitis induced by propylthiouracil (PTU).Method By reporting a case of Antineutrophil Cytoplasmic Antibody-positive Vasculitis induced by PTU. Results The patient (who had been treated with PTU for 3 years because of hyperthyreosis) presented with hypohemia, proteinuria, renal function damage, injury of lungs, positive Antineutrophil Cytoplasmic Antibody.After immunosuppressive therapy, plasma exchange and other treatment, the symptoms of the patients were relieved and the renal function was restored. Conclusions PTU may induce Antineutrophil Cytoplasmic Antibody-positive Vasculitis. Early diagnosis, withdraw of ptu, plasma exchange and administration of glucocortocoid can improve its prognosis.
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Received: 11 March 2015
Published: 09 April 2018
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