Journal of Developmental Medicine(Electronic Version)  2019, Vol. 7 Issue (1): 38-42 DOI: 10.3969/j.issn.2095-5340.2019.01.009 |
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| Clinical investigation for integrating Chinese-western therapy in the treatment of cholangitis after biliary atresia Kasai operation |
| ZHAO Yi-shan LI Yu-lan HAN Juan ZHAO Bao-hong LIU Wen-yue REN Hong-xia
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| 1.Li Yulan Studio, Department of Pediatrics, Taiyuan Traditional Chinese Medicine Hospital, Shanxi, Taiyuan 030013, China; 2.Department of Neonatal Surgery, Children’s Hospital of Shanxi, Shanxi, Taiyuan 030013, China |
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Abstract 【Abstract】 Objective To explore the clinical effect of integrating Chinese-western therapy in the treatment of cholangitis after biliary atresia Kasai operation. Methods From January 2014 to October
2017, 43 cases of children with first time of cholangitis were included and followed up in the Children's
Hospital of Shanxi. All the children with jaundice who were diagnosed as biliary atresia by laparoscopic
exploration and cholangiography performed laparotomy for Kasai surgery. A total of 20 cases with cholangitis were treated with conventional western medicine (control group). The other 23 cases withcholangitis were treated with traditional Chinese medicine Dachaihu decoction combined with western
medicine routine treatment (study group). The basic conditions and alanine transferase (ALT), aspartate
transaminase( AST), total bilirubin (TBIL) and direct bilirubin (DBIL) of pretherapy and post-treatment of
the infants were compared between the two groups. Independent sample t test was used for statistical analysis. Results There was no statistical significance (both P>0.05) at the average age of surgery ［(65.8±7.3) vs (68.6±11.5) d］ and the onset date of cholangitis ［(107.1±8.7) vs (113.1±10.7) d］ in two groups. The following indicators in the study group were lower than that of in the control group: the time that body temperature dropped［(4.4±1.6) vs (8.3±1.5) d］, the time of the jaundice regression ［(9.0±1.2) vs (14.0±0.7) d］ and the length of hospital stay ［ (15.9±0.9) vs (19.5±1.0) d］(all P<0.05). There was no statistical significance in ALT ［(163.0±5.3) vs (164.6±8.8) U/L］ , AST ［(162.4±6.3) vs (164.0±5.9) U/L］, TBIL ［(107.0±2.9) vs (106.8±3.5) μmol/L］ and DBIL ［(72.9±5.3) vs (73.8±2.6) μmol/L］ between the two groups when the onset of cholangitis (all P>0.05). The AST and DBIL of the study group were lower than that of the control group ［AST (51.1±0.9) vs (54.6±0.9) U/L, DBIL (42.0±1.2) vs (45.5±0.9) μmol/L respectively］ at discharge (both P<0.05). Conclusion The addition of Dachaihu decoction on the basis of conventional western medicine treatment can reduce the body temperature effectively, accelerate the jaundice resolution and shorten the hospitalization time of children in the treatment of cholangitis after Kasai postoperative bile duct obstruction.
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Received: 04 March 2018
Published: 01 February 2019
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