Journal of Developmental Medicine(Electronic Version)  2014, Vol. 2 Issue (3): 155-160 DOI: |
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| The detection of inhalant allergens for children with asthma and the analysis of clinical features |
| CHENG Sheng-quan,QIANG Huan, LUO Jian-feng, et al
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| Department of Pediatrics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China |
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Abstract 【Abstract】 Objective This study is aimed to investigate the type and distribution features of allergens inhaled by asthma children as well as their relationship with the age and gender of patients, to provide theoretical basis for the clinical diagnosis, treatment, and prevention of asthma in children. Method 13 types of standardized allergen skin prick liquid, provided by the Danish ALK-ABELL company, were used for inhaled allergen skin prick test （SPT） in 653 cases of children with asthma, treated in the pediatric clinic from July 2008 to July 2013. The patients were divided into three groups by age, <4 years old, 4-7 years old, and 7 -14years old. The SPT-positive rate and changes of allergens species were compared among these three groups
of patients. Result （1）Of the 653 patients，409（62.6%）cases were SPT-positive. The most prevalent inhalant allergens were: Dermatophagns farina in 266 cases（40.7%） , Dermatophagoides pteronyss inus in 265 cases （40.6%）, tropical mite in 162 cases （24.8%）, cat dander in 91 cases （13.9%）, mugwort in 89 cases （13.6%）;（2）The SPT-positive rate in males（299 in 455 cases; 65.7%） was greater than that in females （110 in 198 cases; 55.6%; P<0.05）The top 5 allergens were different between males and females. For males, they are house dust mites, dust mites, tropical mites, mugwort, and dog hair allergens, respectively. And for females, the top five allergens were dust mites, house dust mites, tropical mites, mugwort,
and cat hair, respectively. （3）For <4 years old patients, the female's SPT-positive rate was higher thanmale's whereas male's SPT-positive rate was higher than females in groups of 4-7 years old and 7-14 years old.（4） SPT-positive male children is easier than SPT-positive female children with asthma to inhale three or more kinds of allergens（62.6% in male vs. 50.9% in female; P<0.05）. Conclusion There are differences of gender and age in common inhalant allergens for children with asthma The top four common allergens were Dermatophagns farinae, Dermatophagoides pteronyss inus, tropical mites, and mugwort for
both Female and male children, but the fifth common allergens were dog dander and cat dander for male and female, respectively. In <4-year-old group, the SPT-positive rate of male children with asthma is higher than female children while the SPT-positive rate of female children is higher than males in 4-7 years old groupand 7- 14-years old group. Male children with asthma were more likely to inhale three or more allergens.
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Received: 09 June 2014
Published: 05 September 2019
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