Journal of Developmental Medicine(Electronic Version)  2013, Vol. 1 Issue (3): 150-154 DOI: |
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| Clinical analysis of bilirubin encephalopathy in 82 newborns |
| Nuer ra, YANG Jiao, LI Ming-zhu
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| Department ofNeonatology ofXinjiang Uygur Autonomous Region People's Hospital，Uygur 830000,China |
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Abstract 【Abstract】Objectives The study was designed to analyze the clinical features of bilirubin encephalopathy(BE)in newborns and explore the possible factors that affect the sequelae of patients．Methods Data of 82 newborns suffering from BE were collected from January 1，2008 to January 1，2012 and retrospectively analyzed．The clinical features were summarized and the sernm total bilirubin，total bilirnbin／albumin(B／A)ratio of them were analyzed．The results of the neonatal behavioral score(NBNA)，brain stem auditory evoked potential(BAEP)，and follow—up resuhs were analyzed．Results(1)In this study，
the age BE onset was(4±3)days，with 74 cases(90％)having BE at the age of≤7 days．There were 49 cases(60％)in warning period and 33 cases(40％)in spasmodic of the illness．(2)Fifty cases (60％)suffered from Rh hemolytic disease，25(3 1％)infectious diseases and 15(1 8％)ABO hemolytic disease．(3)The mean TSB in the warning period group was(430±70)¨mol／L，while it Was(560±1 30)斗mol／L in the spasmodic period group．The mean B／A in the warning period group was
(6．8土1．5)mg／g，while it was(8．8±2．1)mg／g in the spasmodic period group with a significantly statistical difference．Conclusion (1)Infants at the age≤7d are easier to have BE．(2)RH hemolytic disease is one of the major factors to BE．(3)TSB and B／A ratio have a positive collection with the extent of bilirubin encephalopathy．(4)In the 45 cases having NBNA examinations，24 had points less than 35．There were 3 cases(13％)in the warning period while 21 cases(88％)in the period of spasticity．Fifly cases had BAEP examinations with an abnormality rate of 53％．(5)In the 41 cases that had a follow up，10 had
sequelae．Between the group with sequelae and that without sequelae．
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Received: 25 April 2013
Published: 06 September 2019
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