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Abstract
【Abstract】 Objective To investigate the distribution and antibiotic resistance of pathogens in neonatal
sepsis in recent 7 years. Methods The distribution of pathogens and their drug resistance of newborns with
neonatal sepsis were retrospectively analyzed in Tongji Hospital, Tongji Medical College Huazhong University
of Science and Technology from January 2012 to December 2018. Results In the past 7 years, the incidence
of neonatal sepsis in neonatal intensive care unit was 2.03% (239/11 780). Among 239 cases of culture
proven neonatal sepsis, 250 pathogenic bacteria strains were found in blood culture including 103 gram
positive bacteria (41.2%), 139 gram-negative bacteria (55.6%), and 8 fungal (3.2%). The annual detection
rates of coagulase-negative staphylococcus (CNS) , streptococcus agalactiae, enterococcus, klebsiella
pneumoniae, escherichia coli were signifificantly different (P<0.05). Of gram-positive bacteria, the detection
rate of CNS (17.6%), streptococcus agalactiae (8.4%), enterococcus (8.4%) and staphylococcus aureus
(5.6%) were primary. CNS were highly resistant to penicillin, cefoxitin and eryphilin (79.5%-97.7%), but
no strains resistant to Linezolid, teicoplanin, and vancomycin had been found. The most common gram
negative bacteria (klebsiella pneumoniae, escherichia coli and enterobacter cloacae) were highly resistant
to penicillin (84.8%-100.0%), but sentitive to tigecycline. Klebsiella pneumoniae showed high resistance
against commonly used cephalosporins such as cefazolin, cefuroxime and cefotaxime (over 90.0%), and
there was still a high rate of resistance to carbapenems (imipenem and meropenem) (46.7% and 45.3%).
Conclusions Neonatal sepsis mainly centers on gram-negative bacteria in our hospital, and its drug
resistance rate is relatively high. The distribution of pathogenic bacteria and drug resistance should be
monitored timely in order to select an optimal antimicrobial therapy
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2020, Vol. 8 
