Journal of Developmental Medicine(Electronic Version)  2021, Vol. 9 Issue (4): 287-291 DOI: 10.3969/j.issn.2095-5340.2021.04.009 |
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| Relationship between miR-30d and endoplasmic reticulum stress in placenta of patients with preeclampsia |
| Wei Qiuyuan, Huang Sujing, Wang Ru, et al
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1. Department of Maternity Care Division, HaikouMaternal and Child Health Hospital, Haikou, Hainan 570203, China; 2. Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Hainan Medical College, Haikou, Hainan 570311, China; 3.Department of Obstetrics and Gynecology, the First Affiliated Hospital of Hainan Medical College, Haikou, Hainan 570300, China
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Abstract 【Abstract】 Objective To explore the relationship between micro-RNA-30d and endoplasmic reticulum
stress in placenta of patients with preeclampsia, and its clinical significance. Methods From October 2018 to September 2019, 30 cases of preeclampsia patients admitted to the Haikou Maternal and Child Health Hospital were selected as the research objects. Another 30 cases of normal delivery in our hospital were used as control. Real-time PCR was used to detect miR-30d. The expression of CCAAT enhancer binding protein homologous protein (CHOP), activating transcription factor 6 (ATF6), glucose regulatory protein 78 (GRP78) in placenta was detected by immunohistochemical analysis. The correlation between miR-30d and the expression of CHOP, ATF6 and GRP78 in placenta was analyzed. T test and Pearson correlation coefficient analysis were used for statistical analysis. Results The 2- △ △ Ct values of miR-30d in preeclampsia group was 0.308±0.072, which was significantly higher than that of 0.115±0.014 in control group with statistical significance (P<0.01). The expression of CHOP, ATF6, GRP78 in placenta of preeclampsia group was significantly higher than that of control group with statistical significance (P<0.01). Pearson correlation analysis showed that the expression of miR-30d in placenta of preeclampsia was positively correlated with CHOP (r=0.517, P<0.05), ATF6 (r=0.452，P<0.05) and GRP78 (r=0.484, P<0.05) expression in preeclampsia patients (P<0.05). Conclusion The high expression of miR-30d in placenta of preeclampsia patients activated endoplasmic reticulum stress, which may be the cause of preeclampsia
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Received: 20 January 2021
Published: 29 July 2021
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