Journal of Developmental Medicine(Electronic Version)  2021, Vol. 9 Issue (5): 341-345 DOI: 10.3969/j.issn.2095-5340.2021.05.004 |
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| Clinical significance of positive thyroid autoantibody in recurrent abortion |
| Liang Jianmei, Lu Xuejing, Liu Xiaoxu, et al
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Department of Obstetrics and Gynecology,Shijiazhuang Maternal and Child Health Hospital, Hebei, Shijiazhuang 050000, China
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Abstract 【Abstract】 Objective To analyze the clinical significance of thyroid autoantibody positive expression on
recurrent abortion. Methods Clinical data of 55 patients with recurrent abortion (recurrent abortion group)and 53 patients with primary abortion (primary abortion group) admitted to the Department of Obstetrics andGynecology of Shijiazhuang Maternal and Child Health Care Hospital from January 2018 to January 2020were retrospectively collected, and 60 healthy patients during the same period were included as the controlgroup. The recurrent abortion group was further divided into two subgroups: two abortions and more thantwo abortions; early abortion and late abortion. The levels of free triiodothyronine (FT3), free thyroxine (FT4),thyroid-stinulating hormone (TSH), thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb)in serum were detected. TPOAb >12.00 IU/ml was positive, and TGAb>34.00 IU/ml was positive. Thepositive rates among the three groups and between the recurrent abortion subgroups were compared. One-wayANOVA and χ2 test were used for statistical analysis. Results There was no significant difference in FT3,FT4 and TSH levels in the recurrent abortion group, primary abortion group and control group (F=2.869, 2.174and 2.989, respectively, P>0.05). The positive rates of TGAb, TPOAb and TGAb/TPOAb in the recurrentabortion group [21.8% (12/55), 23.6% (13/55) and 27.3% (15/55)] were higher than those in the primaryabortion group [11.3% (6/53), 13.2% (7/53) and 17.0% (9/53)] (χ2= 4.325, 4.738 and 5.108, respectively,P<0.05) and control group [1.7% (1/60), 5.0% (3/60) and 5.0% (3/60)] (χ2= 7.732, 7.583 and 8.042, P<0.05);meanwhile, those in primary abortion group were higher than control group (χ2= 4.572, 4.483 and 4.738,respectively, P<0.05). In the recurrent abortion group, the positive rates of TGAb, TPOAb and TGAb/TPOAbwere 23.1% (9/39), 25.6% (10/39) and 33.3% (13/39) in the two abortions subgroup, and 18.8% (3/16), 18.8%(3/16) and 31.3% (5/16) in the more than two abortions subgroup (χ2= 0.125, 0.298 and 2.674, P>0.05). Therates were 27.0% (10/37), 29.7% (11/37) and 32.4% (12/37) in early abortion subgroup, and 11.1% (2/18),11.1% (2/18) and 16.7% (3/18) in late abortion subgroup (χ2=1.798, 2.326 and 1.517, P>0.05). Conclusions The positive rates of TGAb and TPOAb in patients with recurrent abortion are higher than those in patients with primary abortion and the healthy for physical examination. Clinical detection of the positive expression of thyroid autoantibodies can assist clinical diagnosis and treatment to improve the prognosis of pregnant women.
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Received: 08 February 2021
Published: 29 September 2021
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