Journal of Developmental Medicine(Electronic Version)  2022, Vol. 10 Issue (2): 95-100 DOI: 10.3969/j.issn.2095-5340.2022.02.003 |
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| Study on cerebellum development in very low birth weight preterm infants at 40 weeks of corrected gestational age |
| Liu Ruike, Li Guifang, Li Li, et al
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(Department of Neonatology, Cangzhou People’s Hospital, Hebei, Cangzhou 061000, China)
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Abstract 【Abstract】 Objective To examine and evaluate cerebellum development in very low birth weight
(VLBW) preterm infants at 40 weeks of corrected gestational age by cranial ultrasound. Method FiftyeightVLBW premature infants with gestational age less than 32 weeks constituted the premature infant groupand were examined by cranial ultrasound at 40 weeks of corrected gestational age. Forty-eight full-terminfants at 40 weeks of gestational age constituted the full-term infant group and were examined by cranialultrasound at the day of birth. The difference between the two groups for transverse cerebellar diameter andcerebellar vermis height were compared. Premature infants group was divided into extremely prematureinfants group and very premature infants group according to gestational age, 19 extremely premature infantswith gestational age of less than 28 weeks and 39 very premature infants with gestational age of greater thanor equal to 28 weeks. The above cerebellar indicators were compared between the two subgroups. Statisticalanalysis was performed by t test. Result At 40 weeks of correct gestational age, the transverse cerebellardiameters in the extremely premature infants group and very premature infants group were smaller thanthat in the full-term infants group, the differences were statistically significant [(4.05±0.41), (4.29±0.35) vs(4.45±0.31) cm, t=3.647, 2.107, all P<0.05]. The cerebellar vermis heights in the extremely premature infantsgroup and very premature infants group were higher than that in the full-term infants group, but there was nostatistically significant difference (all P>0.05). The transverse cerebellar diameter in the extremely prematureinfants group was smaller than that in the very premature infants group, the difference was statisticallysignificant (t=-2.320, P<0.05). The cerebellar vermis height in the extremely premature infants group wassmaller than that in the very premature infants group, but there was no statistically significant difference(P>0.05). To correct the transverse cerebellar diameter by head circumference, the difference between thetwo groups was statistically significant [(4.27±0.44) vs (4.44±0.34) cm, t=2.167, P<0.05]. No correlationwas found between transverse cerebellar diameter and vermis height and clinical factors before or after
birth. Conclusion The growth of midline structure of the cerebellum is preserved in VLBW premature
infants with gestational age less than 32 weeks at 40 weeks of corrected gestational age, and the growth oflateral structure of the cerebellum decreased. And this may be more obvious in extremely premature infants
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Received: 27 April 2021
Published: 31 March 2022
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