Journal of Developmental Medicine(Electronic Version)  2017, Vol. 5 Issue (4): 224-228 DOI: |
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| Influence of low dosage of inhaled glucocorticoids on height in children with mild to moderate asthma |
| WU Hua-jie, DING Cui-ling, SHI Zhao-ling, LUO Jian-feng, DING Ya-nan, CUI Jia-xin, SUN Xin
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Abstract Objective To explore the influence of low dosage of long-term inhaled glucocorticoids (ICS) on height in children with mild to moderate asthma. Methods From June 2016 to June 2017, 300 cases of children who were diagnosed as mild to moderate asthma in Asthma Clinic of Xijing Hospital, Fourth Military Medical University were included. Fluticasone propionate was adopted as ICS. The subjects were divided into fluticasone propionate group, montelukast group, and drug combination group (fluticasone propionate combined with montelukast), each of group including 50 females and 50 males. Meanwhile, 100 children (50 females and 50 males) of no history of bronchial asthma were selected as control group. The height was measured before and after taking medicine 3, 6 and 12 months. ANOVA and Tukey's Multiple Comparison Test were used for statistically analysis. Results The height trend of males and females were the same. The height growth trend at taking medicine 3 and 6 months between the montelukast group and control group were the same. Meanwhile, height of fluticasone propionate group and drug combination group obviously fell behind montelukast group and control group, but there was no significant difference at taking medicine 12 months. The height of male children at taking medicine 6 months was respectively (117.4±13.0), (119.8±12.6), (114.4±13.0) and (120.8±12.7) cm；that of 12 months was respectively (123.0±12.8), (123.7±12.7), ( 119.0±12.8) and (123.6±12.7) cm（all P﹥0.05）. The height of female children at taking medicine 6 months was respectively (116.0±12.1), (117.7±12.3), ( 114.0±13.2) and (119.6±11.9) cm；that of 12 months was respectively (121.7±12.0), (121.9±12.2), (119.8±12.7) and (122.9±11.6) cm, and there was no significant difference when compared in pairs（all P﹥0.05）. Conclusion There is no inhibiting effect on the growth rate of children with mild to moderate asthma treated by ICS for 12 months.
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Received: 15 August 2017
Published: 24 January 2018
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