Journal of Developmental Medicine(Electronic Version)  2024, Vol. 12 Issue (2): 96-101 DOI: 10.3969/j.issn.2095-5340.2024.02.003 |
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| Expression and significance of serum vitamin D and inflammatory cytokines in neonatal purulent meningitis caused by GBS infection |
| Qiao Mu, Han Yanyan, Yao Wenxiu
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(Department of Neonatology, the First Hospital of Qinhuangdao, Hebei,Qinhuangdao 066000, China)
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Abstract 【Abstract】 Objective To detect the expression levels of interleukin-6 (IL-6), interleukin-10 (IL-
10), tumor necrosis factor (TNF-α) and C-reactive protein (CRP) in purulent meningitis (PM) caused by
group B streptococcus (GBS) infection in neonates, and to discuss their clinical value. Method 59 PM
newborns with GBS infection born in the First Hospital of Qinhuangdao from May 2017 to May 2020 were
included in the observation group, and 59 PM newborns without GBS infection (late-onset sepsis) were
included in the control group during the same period. The levels of serum vitamin D, CRP, IL-6, IL-10
and TNF-α were detected in all subjects, and Pearson correlation analysis was performed. The diagnostic
value of serum vitamin D and inflammatory cytokines in PM neonates with GBS infection was analyzed by
receiver operating characteristic (ROC) curve. The statistical methods performed by t-test, χ2 test and Pearson correlation analysis. Result The pregnant women in the observation group had premature rupture of fetal membrane [47.5% (28/59) and 5.1% (3/59), χ2=27.345], asphyxia during labor [52.5% (31/59) vs 18.6% (11/59)] and [(44.1% (26/59) vs 22.0% (13/59), χ2=6.473] was significantly higher than that of the control group (P<0.05). Serum vitamin D level in the observation group was significantly lower than that in control group [(13.3±2.1)μg/L vs (21.1±5.0) μg/L, t=11.345]. The observation group were significantly higher than those in control group in IL-6 [(87.1±14.5) μg/Land (63.9±11.9) μg/L, t=9.507], IL-10 [(49.6±15.2) μg/L and (29.3±10.0) μg/L, t=8.596], the TNF-α [(76.8±19.0) μg/L vs (50.0±10.8) μg/L,t=9.410] and CRP [(21.5±5.0) μg/L vs (13.7±3.7) μg/L, t=9.702] (P<0.05). The Pearson correlation analysis results showed that the serum vitamin D level in the observation group was negatively correlated with the levels of IL-6, IL-10, TNF-α and CRP, respectively (r=-0.662, -0.644, -0.564, -0.643, P<0.05). The areaunder the curve (AUC) of serum vitamin D, IL-6, IL-10, TNF-α and CRP in the alone diagnosis of neonatalPM with GBS infection were 0.831 (95% CI: 0.757-0.904), 0.887 (95% CI: 0.830-0.944), 0.859 (95% CI:0.793-0.925), 0.888 (95% CI: 0.821-0.955) and 0.879 (95% CI: 0.820-0.938), respectively, and the AUCof five combined tests was 0.991 (95% CI: 0.978-1.000). Conclusion Serum vitamin D levels of PM neonates caused by GBS infection decreased and inflammatory cytokine levels increased, which has certain auxiliary diagnostic value for PM caused by GBS infection.
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Received: 19 December 2022
Published: 29 March 2024
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