Journal of Developmental Medicine(Electronic Version)  2024, Vol. 12 Issue (4): 314-320 DOI: 10.3969/j.issn.2095-5340.2024.04.012 |
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| Research progress of sperm DNA fragmentation detection in clinical evaluation andtreatment of male infertility |
| Zhang Yaodong, Guo Shuxiao, Yan Hongli
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(1.Department of Clinical Laboratory, the 971st Hospital ofPLA, Shandong, Qingdao 266071, China; 2.Department of Reproductive Medicine, Changhai Hospital, NavalMedical University, Shanghai 200433, China)
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Abstract 【Abstract】As the decreasing birth rate and accelerating aging process, the research on improving male
reproductive ability has taken extensive attention in recently years. As a new marker for sperm quality
evaluation, sperm DNA fragmentation index (DFI) has been increasingly used in semen samples detection ofmale infertility. With the publication of clinical expert consensus on sperm DNA fragmentation detection in2023, it provides the basis and standard for sperm DFI to clinical evaluation and treatment of male infertility.This review briefly summarizes the research progress on the relationship between sperm DFI and assistedreproductive technique (ART) treatment outcome, the consistency between sperm DFI and sperm parameters,and the evaluation of clinical sperm DFI detection methods in recent years.
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Received: 07 March 2023
Published: 31 July 2024
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