Journal of Developmental Medicine(Electronic Version)  2024, Vol. 12 Issue (5): 374-379 DOI: 10.3969/j.issn.2095-5340.2024.05.009 |
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| Research progress on neonatal necrotizing enterocolitis and intestinal flora |
| Han Jinbao, Huang Liuming
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Department of Emergency Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China
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Abstract 【Abstract】Neonatal necrotizing enterocolitis (NEC) was common in premature infants and low birth weightinfants, which was the disease with the highest morbidity and mortality in neonatal intensive care units. NEC oftenhad an insidious onset and rapid progression in premature infants and low birth weight infants, causing death orserious sequelae in the early neonatal period. Currently, many studies had confirmed that intestinal flora was closelyrelated to the occurrence of NEC. Before the onset of NEC, the relative abundance of Proteobacteria in infant fecal bacteria increases, while Firmicutes and Bacteroidetes decrease; low flora diversity, low Lactobacillus abundance,and changes in flora network structure were positively correlated with the risk of NEC in premature infants.Therefore, understanding the distribution characteristics of intestinal flora in children with NEC was important forprevention, diagnosis, and treatment of the disease. In-depth study of the interaction between intestinal flora andNEC provides a theoretical basis for further research on NEC.
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Received: 30 May 2024
Published: 30 September 2024
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