Journal of Developmental Medicine(Electronic Version)  2025, Vol. 13 Issue (2): 114-119 DOI: 10.3969/j.issn.2095-5340.2025.02.006 |
|
|
|
|
|
|
| Influencing factors of pulmonary hypertension in infants with bronchopulmonary dysplasia |
| Niu Huixia, Si Liying, Chang Zhixia, et al
|
(Department of Pediatrics, Hebei Hospital of Traditional Chinese Medicine, Heibei, Shijiazhuang 050001, China)
|
|
|
|
Abstract 【Abstract】 Objective To explore the related influencing factors of pulmonary hypertension (PH) in
infants with bronchopuldysplasia (BPD). Method A retrospective study was conducted to select 62
infants with BPD who were admitted to Hebei Hospital of Traditional Chinese Medicine from February 2021
to January 2024 as the study objects, of whom 24 infants were in the BPD group without PH and 38 infants were in the BPD group with PH. The general data, maternal data and clinical characteristics of the two groups were compared. Alveolar-artery oxygen partial pressure gradient (PA-aO2), oxygenation index (OI), B-type natriuretic peptide (BNP), D-Dimer (DD), main pulmonary artery/descending aorta diameter (rPDA), right atrial diameter (RA), right ventricular diameter (RV), left atrial diameter (LA), left ventricular diameter (LV) and other indicators to predict whether infants with BPD combined PH were analyzed. Statistical methods performed by t-test, Mann-Whitney U test, χ2 test, multiple Logistic regression analysis and receiver operating characteristic (ROC) curve analysis. Result The gestational age of the BPD group with PH was lower than that of the BPD group without PH [(27.89±1.13) weeks and (29.49±1.81) weeks, t=-3.760, P<0.001)], and the proportion of hypertensive diseases during pregnancy was lower than that of the BPD group without PH [34.21% (13/38) vs 62.50% (15/24), χ2=4.354, P=0.042], mechanical ventilation time was longer than that in BPD group without PH [276 (123, 462) h vs 69 (12, 175) h, Z=-3.573, P<0.001]. PA-aO2 O2, BNP, DD, rPDA, LV and RA in BPD group with PH were higher than those in BPD group without PH, and OI values were lower than those in PH group without BPD. Multivariate Logistic regression analysis showed that PAaO2 (OR=0.988, 95% CI: 0.979-0.997), rPDA (OR=0.000, 95% CI: 0.000-0.577), RA (OR=0.366, 95% CI:0.167-0.803) could predict the occurrence of PH in children with BPD (all P<0.05). When rPDA≥1.105, PAaO2 >225.000 mmHg, RA≥20.550 mm, the PH of BPD children could be predicted, and the area under theROC curve was 0.760, 0.747, 0.747, respectively. Conclusion PA-aO2, rPDA, and RA are significant in predicting PH in infants with BPD. Clinically, it is essential to closely monitor these indicators in BPD infants and to intervene early to reduce or mitigate the occurrence of complications, thereby improving the prognosis
|
|
Received: 19 July 2024
Published: 31 March 2025
|
|
|
|
|
|
