Journal of Developmental Medicine(Electronic Version)  2025, Vol. 13 Issue (2): 154-160 DOI: 10.3969/j.issn.2095-5340.2025.02.013 |
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| Application progress of sFlt-1/PLGF ratio in preeclampsia |
| Shan Lei, Zhou Tao, Qiu Juanjuan, et al
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(1. Department of Obstetrics, Quzhou Hospital Affiliated to Wenzhou Medical University, Zhejiang, Quzhou 324000, China; 2. Department of Obstetrics, the Affiliated Suzhou Hospital of Nanjing Medical University, Jiangsu, Suzhou 215000, China)
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Abstract 【Abstract】Preeclampsia is one of the most common causes of adverse maternal and neonatal outcomes,even death. The ratio of soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PLGF) as a direct indicator of the dysregulation within placental syncytiotrophoblast cells. This ratio is poised to emerge as a pivotal biomarker for the prediction, auxiliary diagnosis, and prognosis of preeclampsia. This article delineates the pathophysiological role of the sFlt-1/PLGF ratio in the etiology and progression of preeclampsia. Furthermore, it offers a comprehensive summary of the clinical research advancements concerning the application of the sFlt-1/PLGF ratio in diagnosing, predicting, and treatment of preeclampsia.
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Received: 01 February 2024
Published: 31 March 2025
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