发育医学电子杂志  2019, Vol. 7 Issue (1): 70-74 DOI: 10.3969/j.issn.2095-5340.2019.01.016 |
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结构畸形
综述
｜新生儿
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| 肠道黏膜屏障功能评估的研究进展 |
| 高鹏 张旭光 刘雪来 |
| 1. 哈尔滨市儿童医院 普外一科， 黑龙江 哈尔滨150010；2. 哈尔滨市儿童医院 儿童保健科，黑龙江 哈尔滨 150010；3. 首都儿科研究所附属儿童医院 外科，北京 100020 |
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| Advances in the evaluation of intestinal mucosal barrier function |
| GAO Peng ZHANG Xu-guang LIU Xue-lai |
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摘要 肠道具有免疫功能，可将肠道内细菌、毒素阻隔在肠腔内，防止病原微生物及其毒素入侵人体。肠道免疫功能主要靠肠道黏膜屏障实现，各种因素（如免疫、生物、理化）损伤肠道黏膜屏障功能，将出现肠道内菌群移位、内毒素吸收等一系列病理改变［1］。采用合适的方法及时准确地评估肠道屏障功能受损程度，是有效阻止上述病理效应发生的重要手段［2］。目前肠道黏膜屏障功能的评估方法有肠黏膜通透性测定、血浆内毒素测定、肠黏膜 pH 值测定、肠型脂肪酸结合蛋白 (intestinal fatty acid binding protein, IFABP) 含量测定、血浆谷氨酰胺含量测定、大便浆细胞分泌型蛋白（sIgA）含量测定、病理检测等［3］。尿乳果糖和甘露醇比值（ratio of lactulose to mannitol, L/M），血、尿 IFABP 测定方法因其简单、快速、经济等特点，已被广泛应用。本文简述肠道黏膜屏障功能，并对尿 L/M，血、尿 IFABP用于评估肠黏膜屏障功能的研究进展进行综述。
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| 关键词:
肠道黏膜屏障')" href="#">肠道黏膜屏障
肠型脂肪酸结合蛋白
尿乳果糖和甘露醇比值
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收稿日期: 2018-09-15
出版日期: 2019-01-30
发布日期: 2019-02-02
期的出版日期: 2019-01-30
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| 基金资助: 哈尔滨市科技局青年后备人才项目（2016RAQYJ145） |
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通讯作者:
刘雪来https://tieba.baidu.com/p/3685087042?red_tag=1345955938
E-mail: liuxuelai_steven@163.com
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| [1] |
GAO Xiao-hui, MAO Jian. Clinical features of non-oliguric hyperkalemia in extremely low birth weight infants[J]. Journal of Developmental Medicine(Electronic Version), 0, (): 152
. |
| [2] |
Society of Neonatologist, Chinese Medical Doctor Association. Consensus recommendations on the prevention and early management of respiratory distress syndrome in preterm infants[J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 129
-131
. |
| [3] |
Professional Committee of Respiratory, Society of Neonatologist, Chinese Medical Doctor Association. Clinical application recommendations for heated humidified high flow nasal cannula[J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 132
-135
. |
| [4] |
YAN Jun, ZHU Xing-wang, SHI Yuan. Application progress of noninvasive ventilate technique for premature infants[J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 136
-140
. |
| [5] |
GU Min-fang, YANG Chuan-zhong. Progress of intrapartum resuscitation for premature infants[J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 141
-145
. |
| [6] |
LIU Shu-hua, SHEN Yue-bo, LIU Cui-qing, MA Li. The efficacy of pulmonary surfactant for pulmonary function in premature tension pneumothorax[J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 146
-151
. |
| [7] |
GAO Xiao-hui, MAO Jian. Clinical features of non-oliguric hyperkalemia in extremely low birth weight infants[J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 152
-158
. |
| [8] |
XIA Yao-fang, YANG Juan , TIAN Bao-li, et al. Value of amplitude-integrated electroencephalography in monitoring acute period of neonatal bilirubin encephalopathy and prognostic assessment[J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 159
-163
. |
| [9] |
WANG Li-rong, SUN Xiao-yan, ZHU Ruo-xin, et al. Epidemiological investigation and analysis of women aged 40-55 years old with osteoporosis in Gansu province[J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 164
-167
. |
| [10] |
CHEN Ru-yue, SHEN Yun-yan, CHEN Qing , et al. Five cases about Henoch-Schönlein purpura complicated with central nervous system injury in children and literatures review[J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 168
-171
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