发育医学电子杂志 Vol. 1 136-139
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论著
135例羊水量异常与染色体相关性探讨
徐慧 郭芬芬 李军 燕风 徐盈 张建芳 王德堂 陈必良
第四军医大学第一附属医院 1．妇产科，2．超声科，西安710032
Study of 135 eases of amniotie fluid volume abnormalities associated with chromosome
XU Hui, GUO Fenfen, LI Jun, et al
1. The Department of Gynecology and Obstetrics；2. Department of Uetrasovnd,Xijing Hospital,Xi"an 710032,China
摘要 【摘要】目的 探讨孕期妇女羊水量异常与胎儿染色体核型异常的相关性。方法 对孕21—35周超声诊断羊水量异常的妇女，临床建议给予羊水或脐血穿刺取样，经细胞培养后进行胎儿染色体核型分 析。结果 135例样本检测出异常核型19例，异常比例14．1％。其中羊水量多112例，异常核型17 例，异常比例15．2％；羊水量少23例，异常核型2例，异常比例8．7％。异常核型中2l三体5例， 18三体7例(其中1例嵌合型)，染色体多态性变异4例，45，XO 2例(1例嵌合型)，l例标记染 色体嵌合型。结论 胎儿染色体异常可以导致孕期羊水量过多或过少，对孕期超声诊断羊水量异常的 妇女，应该建议其进行胎儿染色体核型分析。妊娠期胎儿异常核型的检出，避免了缺陷儿的出生， 提高了我国国民的整体素质。
关键词:
羊水量')" href="#">羊水量
产前诊断
细胞培养
染色体
Abstract: 【Abstract】Objectives To investigate pregnant women amniotic fluid volume abnormalities associated with fetal karyotypes．Methods abnormalities women were diagnosed amniotic fluid volume abnormalities by ultrasound during 21-35w．We suggested that clinical recommendations given amniocentesis or sampling umbilical cord，then cultured cells and analysed fetal karyotype．Results There are abnormal karyotypes 1 9 in all 135 cases，abnormal ratio of 14．1％．Polyhydramnios is 1 12 cases，17 cases of abnormal kalyotypes，abnormal ratio of 15．2％．Oligohydramnios is 23 eases，2 cases of abnormal kalyotype，the abnormal ratio of 8．7％．There ale 5 cases with trisomy 21，7 cases with trisomy 18(one case is chimeric)，4 cases with chromosome polymorphism variation，2 cases with 45，XO(one case is chimeric)，a case with Marker chromosome chimeric．Conclusion fetal chromosomal abnormalities may lead to amniotic fluid volume abnormalities during pregnancy，we should recommended pregnant women with abnormal amniotic fluid volume analysed fetal karyotype．Karyotype anlysis of the fetus during pregnancy avoids boming defects and improving the overall quality of Chinese population．
Key words:
Amniotic fluid volume')" href="#">Amniotic fluid volume
Prenatal diagnosis
Biocytoculture
Chromosome
收稿日期: 2013-05-19
出版日期: 2013-07-30
发布日期: 2019-09-06
期的出版日期: 2013-07-30
通讯作者:
张建芳https://ysk.familydoctor.com.cn/169577/
E-mail: zhzhhao@163．tom
引用本文:
徐慧 郭芬芬 李军 燕风 徐盈 张建芳 王德堂 陈必良. 135例羊水量异常与染色体相关性探讨 [J]. 发育医学电子杂志, 2013, 1(3): 136-139.
Study of 135 eases of amniotie fluid volume abnormalities associated with chromosome . Journal of Developmental Medicine(Electronic Version), 2013, 1(3): 136-139.
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