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发育医学电子杂志  2013, Vol. 1 Issue (2): 83-86    
  论著 |
不同微量血胆红素值与畸变产物耳声发射的相关性研究
林新祝 刘生荣 郑直 李雅丹 赖基栋
厦门市妇幼保健院林巧稚妇儿医院1.新生儿科,
2.听力筛查中心,厦门361000
    
Correlation between serum billrubin and distortion product otoaeoustic emission
LIN)(in-zhu,L儿,Sheng-rong,ZHENG ZhL
Xiamen
Maternal and Chfd Health
Hospital lNeonatalDeparO'nent;2Hearing Screening Center,Xiamen 361000,China
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摘要 【摘要】目的探讨不同微量血胆红素值与畸变产物耳声发射(DPOAE)的相关性,并提出胆红
素干预的阈值。方法选择2007年1月至2009年12月在我院出生的足月顺娩新生儿630例,分
别测定微量血胆红素值与DPOAE的通过率,所有病例均排除高危因素,从85斗mol/L开始,到
444.6斗mol/L,每增加17.1斗mol/L为一个测定段,共有21个测定段,每段有30例。根据微量血胆
红素值与第1次筛查出现不能通过的例数进行相关和回归分析。结果630例新生儿第1次DPOAE筛
查未通过有25例,其中10例左耳,12例右耳,3例为双侧,占3.97%;最后确诊耳聋病例有2例,
其中l例左耳,l例为双侧,均为轻度耳聋,占0.32%。在微量血胆红素值239.4斗mol/L时(第10
测定段),出现第l例DPOAE未通过病例,以后随着微量血胆红素值的增高,DPOAE未通过病例逐
渐增多,直线回归方程:y-一2.0105+0.2587X,P=O.0009,所以两个变量间有直线回归关系。回归系
数b=0.2587,即胆红素测定段数每变动1,DPOAE异常例数平均变动0.2587个。结论微量血胆红素
值为239.4~256.5“mol/L(第10测定段)为干预的阈值,即应给予及时干预,以期尽快降低胆红素
值,避免胆红素神经毒性的出现。
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关键词:  微量血胆红素  畸变产物耳声发射  脑干听觉诱发电位  听力损害    
Abstract: 【Abstract】Objectives
To
explore
the correlation between serum bilirubin and distortion
product
otoacoustic emission(DPOAE).and
get
the threshold of bilirubin for intervention.Methods 630 cases
of term
infants,spontaneous labor,from January
2007 tO December
2009,were
tested for seFilm bilirubin and
distortion
product
otoacoustic emission.From 85斗mol/1 to 444.6斗mol/1 of bilirubin,every 17.1肛tool/1 was
regarded
as a
range
interval which included 30
cases.Regression analysis
was applied for correlation analysis
of serum bilirubin and eases who didn’t past the first DPOAE test.Results Theres 25 cases f3.97%)who didn。t
past
the first test
among
630
cases,10
cases for left
ear,1 2
cases for
right ear,and
3 cases for both.2 cases
(0.32%)were finally diagnosed
as
deafness,one
for left
ear,and
the other for both ears.The first case who didnlt
past
the first DPOAE test at the time when bilirubin reached 239.4斗mol/L(tenth range interval).With the
increase in bilirubin value,the number of cases who failed to the test increased.The linear regression equation
was written as
y=一2.0105+0.2587X(P-0.0009),suggesting
the
relationship
of linear
regression
between two
variables.Conclusion When serum bilirubin reached 239.4—256.5“mol/L,we should take measures to
decrease level of bilirubin and avoid bilirubin-assoeiated neurotoxicity.
Key words:  erum bilirubin    Distortion product
otoacoustie emission
   Brain stem
auditory
evoked
potential
   Hearing impairment
               出版日期:  2013-04-30      发布日期:  2019-09-07      期的出版日期:  2013-04-30
引用本文:    
林新祝 刘生荣 郑直 李雅丹 赖基栋. 不同微量血胆红素值与畸变产物耳声发射的相关性研究[J]. 发育医学电子杂志, 2013, 1(2): 83-86.
LIN)xin-zhu, Liu Sheng-rong, ZHENG ZhL. Correlation between serum billrubin and distortion product otoaeoustic emission. Journal of Developmental Medicine(Electronic Version), 2013, 1(2): 83-86.
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