Abstract: Objective To investigate the therapeutic effect of intranasal duo positive airway pressure (DuoPAP) combined with caffeine in the treatment of repeated apnea of very low birth weight infants. Methods From January 2014 to December 2015, in neonatal department of the People's Hospital of Gaoming District, Foshan, 90 cases with recurrent apnea were included in this study by the following criteria: gestational age <32 weeks, birth weight <1 500 g, within 24 hours after admission, without diseases of congenital heart disease and hereditary metabolic diseases. The patients were randomly divided into DuoPAP group (46 cases) and nasal continuous positive airway pressure (NCPAP) group (44 cases). Patients of the two groups were given warm, nutritional support treatment, as well as caffeine citrate intravenous infusion. DuoPAP group used the Swiss fabian neonatal and pediatric ventilator (CE0124), while NCPAP group used the United States Stephan CPAP ventilator. The treatment effect (marked effective, effective or ineffective) and complications of intraventricular hemorrhage (IVH), bronchopulmonary dysplasia (BPD) and necrotizing enterocolitis (NEC) were compared between the two groups. Results There were no significant differences in sex ratio, gestational age and birth weight between the DuoPAP group and the NCPAP group (P>0.05). The marked effective rates of DuoPAP group and NCPAP group were 50.0% (23/46) vs 29.5% (13/44), and the effective rates were 41.3% (19/46) vs 20.5% (9/44), indicating that the effect of DuoPAP group was better (P<0.05). There were no significant differences between the two groups of BPD ［4.3% (2/46) vs 6.8% (3/44)］, NEC ［4.3% (2/46) vs 4.5% (2/44)］ and IVH ［4.3% (2/46) vs 4.5% (2/44)］ (all P>0.05). Conclusions Intranasal DuoPAP combined with caffeine can effectively relieve the repeated apnea of very low birth weight infants without increasing the risk of complications.
肖厚兰, 林多华, 孙世兰, 等. 经鼻双水平正压通气模式联合咖啡因治疗极低出生体重儿呼吸暂停的临床研究[J]. 发育医学电子杂志, 2017, 5(1): 18-21.
XIAO Hou-lan, LIN Duo-hua, SUN Shi-lan, et al. Clinical research for intranasal duo positive airway pressure combined with caffeine in the treatment of apnea of very low birth weight infants. Journal of Developmental Medicine(Electronic Version), 2017, 5(1): 18-21.
2017, Vol. 5 
