Expression and significance of adiponectin, serum adiponectin, chemerin, hs-CRP and insulin resistance in pregnant woman with gestational diabetes mellitus
LIANG Yang, YAO Da-wei
Center of Health Examination, The Fourth Affiliated Hospital of Harbin Medical University, Heilongjiang, Harbin 150000, China
Abstract: 【Abstract】 Objective To analyze the relationship between adiponectin, serum adiponectin, chemerin, high-sensitivity C-reactive protein (hs-CRP) level and insulin resistance in pregnant women with gestational diabetes mellitus (GDM) and investigate the pathogenesis of GDM. Methods From January 2016 to December 2017, 80 pregnant women with GDM and 80 healthy pregnant women in The Fourth Affiliated Hospital of Harbin Medical University were selected as observation group and control group. The fasting blood was collected to detect serum adiponectin, chemokine, and hs-CRP level, and the insulin resistance index was calculated based on the blood glucose and insulin test results. Placental tissue was taken after delivery and the expression level of placental adiponectin was detected by immunohistochemistry. Thepregnant women with GDM were further divided into insulin resistance group and no insulin resistance group, and the correlation between the above indicators and GDM, insulin resistance index was analyzed. The statistical analysis was performed by t test and Pearson correlation coefficient analysis. Results The serum adiponectin level and placental adiponectin level in the GDM group were lower than those in the control group. Insulin resistance index and hs-CRP, chemerin level were higher than those in the control group, which was statistical significance (P﹤ 0.001). Among the 80 pregnant women with GDM, 58 cases had insulin resistance and the other 22 cases had no insulin resistance. Serum adiponectin and placental adiponectin level in the insulin resistance group were lower than those in the non-insulin resistant group. Hs-CRP and chemokine level were higher than those in the non-insulin resistant group, which was statistical significance (P﹤0.05). Binary logistic regression analysis showed that serum adiponectin and placental adiponectin level were negatively correlated with the occurrence of GDM (r values were ?0.786 and ?0.803, respectively, P﹤0.05). Insulin resistance, hs-CRP, and chemokine level were positively correlated with the occurrence of GDM (r values were 0.758, 0.621, and 0.633, respectively, P﹤ 0.05). Serum adiponectin and placental adiponectin level were negatively correlated with insulin resistance (r values were ?0.723 and ?0.709, respectively, P﹤0.05), however hs-CRP and chemokine level were positively correlated with insulin resistance (r values were 0.647 and 0.598, respectively, P﹤0.05). Conclusions Insulin resistance exists in pregnant women with GDM, whose serum adiponectin and placental adiponectin level decreases,while hs-CRP and chemokine level increases. These indicators are closely related to the insulin resistance index and worth paying much more attention.
2019, Vol. 7 
