Analysis of disease spectrum and mortality rate of all hospitalized neonates by gestational age
Zhang Fangyuan, Zhai Shufen, Hua Shaodong, et al
1. Health Science Center, Hebei University of Engineering, Heibei, Handan 065002, China; 2. Department of Neonatology, Handan Central Hospital, Heibei, Handan 056001, China; 3.Faculty of Pediatrics, Chinese PLA General Hospital, Beijing 100700, China; 4.Department of Neonatology, BaYi Children’s Hospital, Seventh Medical Center of Chinese PLA General Hospital, Beijing 100700, China
Abstract: 【Abstract】 Objective To analyze all hospitalized neonatal patients in Handan Central Hospital in 2018, including their spectrum of diseases, perinatal exposure as risks, and cause of death, to standardize and improve clinical treatment. Methods The clinical data of 1 842 hospitalized neonates werecollected in Handan Central Hospital from January to December in 2018. The spectrum of diseases, perinatal exposure and cause of death were analyzed by independent risk factors. Statistical methods performed by χ2 and signed rank sum test. Results ① Of all hospitalized neonates, there were maleto- female ratio of 1.32∶1; preterm infants accounted for 44.8% (825/1 842). ② 64.8% (1 194/1 842) mothers encountered significant pregnancy complications; with increasing gestational age, there was a trend of lower prevalence of pregnancy complications, premature rupture of membranes, hypertension of pregnancy, preeclampsia/eclampsia showed downtrend (P<0.01), but prevalence of amniotic fluid contamination was increased (P<0.01). ③ The incidence of birth defects was 9.1% (168/1 842). ④ The top five diseases of the hospitalized neonates were pneumonia, hyperbilirubinemia, intracranial hemorrhage, sepsis and respiratory disease syndrome. The incidence of pneumonia, respiratory disease syndrome, asphyxia, intracranial hemorrhage and hypoglycemia in premature infants was higher than in the term infants (P<0.01), but the incidence of hyperbilirubinemia and purulent meningitis in preterm infants was lower than in the term infants (P<0.05). ⑤ There were 2.9% (54/1 842) of the hospitalized neonates death rate, very preterm infants (<32 weeks gestation) were the main group of the deaths of the neonatal infants, accounted for 50.0% (27/54).⑥ Birth defects, small for gestational age, low birth weight were independent risk factors for the deaths of the infants. Conclusions The Hospitalized newborn infants diseases were predominantly composed of Pneumonia, jaundice, sepsis, asphyxia, respiratory distress syndrome(RDS). Very preterm infants (<32 weeks gestation) were the main group of the deaths of the neonatal infants.These results suggest that by analyzing prevalence and mortality rate of all hospitalized neonatal patients,it may be served as a baseline for characteristics of a tertiary perinatal-neonatal center of a region for quality improvement in the care of very preterm and critically ill neonatal infants.
2021, Vol. 9 
