Influence of gestational diabetes mellitus on neonatal braindevelopment evaluated by amplitude-integratedelectroencephalogram
LI Jia, HOU Xin-lin
LI Jia1,2, HOU Xin-lin1 (1.Department of Pediatrics, Peking University First Hospital, Beijing 100034, China; 2.Department of Pediatrics, Civil Aviation General Hospital, Beijing 100011, China)
Abstract: 【Abstract】Objective To evaluate the influence on neonatal brain development by amplitude-integrated electroencephalogram (aEEG) under different levels of glucose control in gestational diabetes mellitus (GDM) women. Methods A total of 115 newborns delivered in Peking University First Hospital from January 2009 to April 2015 were enrolled in the study, whose mothers were diagnosed as GDM. According to the level of blood glucose control, the mothers were divided into satisfied and unsatisfied group, and each group was divided into diet-exercise and insulin therapy sub-group. The blood glucose of newborn was tested within 30 min after birth. The aEEG monitoring was performed within 72 hours after birth. If one of the three indicators (amplitude, primitive EEG and sleep cycle) was abnormal, the result of aEEG was judged to be abnormal. The ratio of posterior horn of lateral ventricle was detected by ultrasound, and the ration >0.5indicated abnormal. Chi-square was use to compare the aEEG results of the newborns between different levels of maternal blood glucose control. Results The percentage of abnormal aEEG cases in the satisfied group was lower than that in the unsatisfied group[13% (11/88) vs 85% (23/27), χ2=52.4, P﹤0.05]. In the satisfied group, the percentages of abnormal aEEG cases between the diet-exercise and insulin therapy sub-group were 11% (8/74) and 21% (3/14) respectively, without statistical difference (χ2=1.2, P>0.05). In the unsatisfied group, the percentages of abnormal aEEG cases between the diet-exercise and insulin therapy subgroup were 83% (20/24) and 100% (3/3) respectively, without statistical difference (χ2=0.6, P>0.05). 34 cases were found abnormal results of aEEG. 23 cases showed mild abnormal amplitude, and there were no severe abnormal cases. All the 34 cases showed discontinuous primitive EEG. The percentage of abnormal aEEG cases between normal blood glucose group and hypoglycemia group were 27% (11/41) and 31% (23/74) respectively, without statistical difference (χ2=0.2, P>0.05). In 72 newborns, the results of aEEG and cranial ultrasonography were both normal; while in 13 cases, the results of the two examinations were both abnormal. The diagnostic coincidence rate was 74% (85/115). Conclusions If the level of blood glucose control of GDM mother is unsatisfied, the the neonatal brain development will be affected. And aEEG is helpful to evaluate the neonatal brain development.
2016, Vol. 4 
