Abstract: 【Abstract】 Objective To explore the association between functional gastrointestinal diseases (FGIDs) and physical development in children with autism spectrum disorders (ASD). Methods A total of 35 ASD children complicated with FGIDs in Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region from October 2019 to January 2020 were enrolled as the observed group. According to 1∶2 ration,70 cases of ASD without FGIDs were enrolled as the control group. Questionnaires were conducted on the parents to find out the demographic data, dietary frequency, children's eating behaviors and feeding methods. The children's length or height, weight and head circumference were measured, and Z score of the weight-forheight, height-for-age, weight-for-age, BMI (body mass index)-for-age and head circumference-for-age were calculated. The Rank-sum test, χ2 test, Spearman rank correlation and generalized linear model (GLM) were used for statistical analysis. Results There was no significant difference in the maternal age at delivery, mother's education level, father's age, mother's work, father's work, residence and family income between the two groups (P>0.05). The weight-for-height Z score of the observation group and the control group [–0.31 (–1.01-0.37) vs 0.05 (–0.38-0.99), Z= –2.325], the weight-for-age Z score [–0.38 (–1.10-0.36) vs 0.11(–0.41-0.65), Z= –2.098] and BMI-for age Z score [–0.27 (–1.05-0.61) vs 0.04 (–0.30-0.92), Z= –2.036] werecompared, and those of the observation group were lower than the control group (P<0.05). The frequency of eating dry nuts was positively correlated with the head circumference-for-age Z score (rs=0.192, P<0.05).The frequency of fungus eating was negatively correlated with the weight-for-height and BMI-for-age Z score (rs= –0.247 and –0.236, P<0.05). Picky eating was positively correlated with height-for-age and weightfor- age Z score (rs = 0.232 and 0.215, P<0.05). Food preference was negatively correlated with weight-forheight Z score (rs= –0.210, P<0.05). Parents' worry about their children's weight was positively correlated with head circumference-for-age Z score (rs=0.338, P<0.05). The results of the GLM analysis showed that FGIDs was negatively correlated with weight-for-height, weight-for-age, and BMI-for-age Z scores (P<0.05).The change trend of boys was consistent with that of children in general (P<0.05), but girls' FGIDs had nocorrelation with various physical development indexes (P>0.05). Conclusion FGIDs in ASD children are related to weight-for-height, weight-for-age and BMI-for-age, especially in boys.
吴薇岚 江蕙芸 陈雪 朱才荣 罗宇阳 李俐娇 沈榕 韦丽萍. 功能性胃肠病与孤独症谱系障碍儿童体格发育的相关性[J]. 发育医学电子杂志, 2021, 9(6): 406-412.
Wu Weilan, Jiang Huiyun, Chen Xue, et al. Association between functional gastrointestinal diseases and physical development in children with autism spectrum disorders. Journal of Developmental Medicine(Electronic Version), 2021, 9(6): 406-412.
2021, Vol. 9 
