Effect of early cognitive training combined with repetitive transcranial magnetic stimulation in the rehabilitation of neonatal bilirubin encephalopathy
Yang Xiaoxi, Wu Xianglan
(1. Department of Rehabilitation, Longhua People's Hospital of Shenzhen,Guangdong, Shenzhen 518109, China; 2. Department of Neonatology, Longhua People's Hospital ofShenzhen, Guangdong, Shenzhen 518109, China
Abstract: 【Abstract】 Objective To explore the effect of early cognitive training combined with repetitive transcranial magnetic stimulation in the rehabilitation of neonatal bilirubin encephalopathy. Method From September 2016 to September 2019, 88 cases of neonates with bilirubin encephalopathy were followed up in the High-Risk Children's Clinic of Longhua District People's Hospital in Shenzhen. The cases were included Systematic high-risk follow-up management and intervention from the High-Risk Children's Clinic and Rehabilitation Department within 3 days of being discharged from the hospital. According to the parents' wishes, the cases were divided into the control group (n=50, received early cognitive training) andthe observation group (n=38, given early cognitive training combined with it repeat transcranial magneticstimulation treatment), the cases with different month-old neonatal behavioral neurological assessment(NBNA), children's developmental center of China (CDCC), 0-6 evaluation of the neuropsychologicaldevelopment checklist (child-cardiac scale) for children at age were compared between the two groups.Statistical methods were performed by t-test χ2 test. Result At the age of 1 month, the NBNA score in theobservation group was higher than that in the control group [(35.7 ±4.4) vs (31.8±2.9) points], which wasstatistical significance ( t=10.108, P<0.05). Mental development index (MDI) and psychomotive developmentindex (PDI) values of the two groups were higher than that of the three months, and the observation group washigher than that in the control group at 6, 9 and 12 months after intervention, which was statistical significance(P<0.05). The cases was evaluated with the child - heart scale at 12 months, the observation group wasbetter than the control group in the fine motor, big movement, language, flexibility, social communicationand development business indicators were significantly improved, the difference was statistically significant(P<0.05). Conclusion Early cognitive training combined with repetitive transcranial magnetic stimulationin the rehabilitation of neonatal bilirubin encephalopathy has remarkable clinical rehabilitation effect and is worthy of promotion
杨晓茜 吴湘兰. 早期认知训练联合重复经颅磁刺激在新生儿胆红素脑病康复中的应用效果[J]. 发育医学电子杂志, 2022, 10(2): 101-106.
Yang Xiaoxi, Wu Xianglan. Effect of early cognitive training combined with repetitive transcranial magnetic stimulation in the rehabilitation of neonatal bilirubin encephalopathy. Journal of Developmental Medicine(Electronic Version), 2022, 10(2): 101-106.
2022, Vol. 10 
