Abstract: Objective To explore the effects of mouse nerve growth factor (mNGF) on infants with central coordination disturbance (CCD). Methods From December 2015 to December 2016, 60 infants diagnosed CCD in Department of Neurology and Development of Bayi Children's Hospital Affiliated to PLA Army General Hospital were divided into mNGF treatment group and control group randomly, 30 cases for each group. The treatment group accepted rehabilitation therapy and mNGF injection, as well as the control group got rehabilitation therapy. The developmental quotient of two groups was confirmed by Gesell development tests before and after the therapy to assess the therapeutic effects. Statistical analysis was performed by t test and χ2 test. Results There was no statistical significance in gender, age and grading of CCD of two groups (P﹥0.05). And there was also no statistical significance in Gesell score between mNGF group and control group ［(60.1±16.0) vs (58.2±14.4) point, t=1.882, P﹥0.05］before the therapy. After the therapy, the Gesell score of mNGF group was higher than that of control group ［(72.0±16.4) vs (64.4±15.8) point, t=7.916, P﹤0.05］, effective rate of mNGF group was higher than that of control group［53.3% (16/30) vs 26.7% (8/30), χ2=2.040］, invalidity rate of mNGF group was lower than that of control group［20.0% (6/30) vs 43.3% (13/30), χ2=?2.198］, and the differences were statistically significant (both P﹤0.05). There were no obvious adverse reactions in both groups. Conclusion Application of mNGF can obviously benefit the treatment of CCD with advantage of higher security and suitable for clinical use.
2017, Vol. 5 
