Quantitative evaluation of left ventricular systolic function in children with Kawasaki disease by left ventricular pressure-strain loop
Cao Xufeng, Niu Haiyan, Wei Wei, et al
(1. Department of UltrasoundDiagnosis, the Seventh Medical Center of PLA General Hospital, Beijing 100700, China; 2. Departmentof Pediatric Medicine, the Seventh Medical Center of PLA General Hospital, Beijing 100700, China;3.Department of Ultrasound, Tongji Shanxi Hospital, Shanxi Academy of Medical Sciences, Shanxi Bethune Hospital, Shanxi,Taiyuan 030032, China)
Abstract: 【Abstract】 Objective To evaluate left ventricular systolic function in children with Kawasaki disease (KD) with different degrees of lesion by non-invasive left ventricular pressure-strain loop (LVPSL) Method A total of 55 pediatric patients with KD admitted to the Seventh Medical Center of PLA General Hospital from September 2020 to December 2022 were included in the study. KD patients were divided into dilation group (n=21) and undilation group (n=34) based on the presence or absence of coronary artery dilation. Twenty-eight healthy children matching the age and gender of the KD group in the same period were selected as the control group. KD patients and healthy children underwent echocardiography. The left ventricle global longitudinal strain (GLS), global work index (GWI), global constructive work (GCW),global wasted work (GWW), and global work efficiency (GWE) were calculated. The left ventricular conventional echocardiography and myocardial work parameters among the three groups were compared, andthe correlation between myocardial work parameters and GLS and N-terminal pro B-type natriuretic peptide(NT-proBNP) were analyzed. Statistical methods performed by χ2 test, one-way ANOVA, LSD-t test andPearson correlation analysis. Result There was no significant differences in conventional echocardiography parameters among the three groups (all P>0.05). The GLS, GWI and GCW in dilation group were lower than those in control group and undilation group [GLS: (-19.5±2.9) % vs (-21.6±2.1) %, (-21.4±2.4) %; GWI:(1 259±225) mm Hg%vs (1 490±239) mm Hg%, (1 459±233) mm Hg%; GCW: (1 493±236) mm Hg% vs(1 687±226) mm Hg%, (1 644±290) mm Hg%, all P<0.05］, the GWW in dilation group was higher thanthat in control group and the undilation group [(66±29) mm Hg% vs (49±23) mm Hg%, (53±20) mm Hg%,all P<0.05]. There were no statistically significant differences in GLS, GWI, GCW and GWW among theundilation group and the control group (all P>0.05), and there were no statistically significant differencesin GWE among the three groups (all P>0.05). The results of Pearson correlation analysis showed that, theGLS was negatively correlated with GWI and GCW (r=-0.717, P<0.001; r=-0.791, P<0.001). The GWI andGCW were negatively correlated with NT-proBNP (r=-0.749, P<0.001; r=-0.702, P<0.001). Conclusion Noninvasive LVPSL can quantitatively evaluate the changes in left ventricular myocardial work of KD children with different degrees of lesion, and it can early and sensitively reflect left ventricular systolic function damage
曹旭峰 牛海燕 卫炜 隋超 张宁 苏莉莉. 左心室压力- 应变环评估川崎病患儿左心室收缩功能的定量研究[J]. 发育医学电子杂志, 2024, 12(2): 108-113.
Cao Xufeng, Niu Haiyan, Wei Wei, et al. Quantitative evaluation of left ventricular systolic function in children with Kawasaki disease by left ventricular pressure-strain loop. Journal of Developmental Medicine(Electronic Version), 2024, 12(2): 108-113.
2024, Vol. 12 
