Effect of Qi Lin Wan applied to patients with diminished ovarian reserve treated by in vitro fertilization and embryo transfer
XU Chen, WANG Liang, Li Wen, et al
XU Chen, WANG Liang, LI Wen, SUN Ning-xia, ZHANG Qing, PANG Wen-juan, CAO Yan (Center for Reproductive Medicine, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China)
Abstract: Objective To discuss the effect of Qi Lin Wan applied to patients treated by in vitro fertilization and embryo transfer (IVF-ET) with diminished ovarian reserve (DOR). Methods From January 2013 to March 2015, 120 patients with DOR who were going to receive in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) were enrolled in Center for Reproductive Medicine, Shanghai Changzheng Hospital, Second Military Medical University. Patients were randomly divided into traditional Chinese medicine group and control group, 60 cases in each group. On the third day of menstrual cycle, the patients in control group were given routine mild stimulation. The patients in traditional Chinese medicine group took Qi Lin Wan orally for 2 months before menstrual cycle, and continued to take Qi Lin Wan afterentering cycle and received the routine mild stimulation until the trigger. All patients received frozen-thawed embryo transfer of replacement cycle. The age, years of infertility, basal level of follicle stimulating hormone (FSH) and estradiol, antral follicle count (AFC), dose of gonadotropin (Gn), days of super ovulation, number of retrieved oocytes, number of embryos and rate of pregnancy in the two groups were analyzed. The Chi-square test and paired t test were used for statistical analysis. Results The average age of 120 patients was (38.5±2.3) years, years of infertility were 1~20 years. 52 cases were primary infertility and 68 cases were secondary infertility. The basal level of FSH in traditional Chinese medicine group was lower than that in control group ［(9.2±3.2) vs (11.0± 3.4) U/L, t =2.034, P<0.05］, and AFC were higher than those in control group ［(7.4±2.7) vs (6.1±2.1), t =2.001, P<0.05］. Although there were no statistical differences in days of super ovulation and dose of Gn (P>0.05), the number of retrieved oocytes in traditional Chinese medicine group was higher than that in control group ［(4.4 ± 2.2) vs (3.3± 2.2), t =2.132, P<0.05). So was the rate of pregnancy ［53.3% (32/60) vs 46.7% (28/60), χ2=2.819, P<0.05)］. Conclusion The adjuvant therapy of Qi Lin Wan can improve the ovarian reserve function of DOR patients, improve ovarian response and the outcomes of IVF-ET treatment
徐晨 王亮 李文 等. 麒麟丸对卵巢储备功能减退患者体外受精-胚胎移植的影响[J]. 发育医学电子杂志, 2016, 4(3): 158-162.
XU Chen, WANG Liang, Li Wen, et al. Effect of Qi Lin Wan applied to patients with diminished ovarian reserve treated by in vitro fertilization and embryo transfer. Journal of Developmental Medicine(Electronic Version), 2016, 4(3): 158-162.
2016, Vol. 4 
