Comparative of nutritional metabolism and body composition differences between obese patients with polycystic ovary syndrome and general obese patients
Fu Wenwen, Zhang Li'na, Xie Fengmei, et al
Department of Clinical Nutrition, The SixthAfliated Hospital, Sun Yat-sen University, Guangdong, Guangzhou 510655, China
Abstract: 【Abstract】Objective To investigate the differences in body composition, nutritional metabolic indicators, and dietary structure between obese patients with polycystic ovary syndrome (PCOS) and obese patients with general obesity. Method The obese patients with PCOS (PCOS obese group, n=918) and obese patients with general obesity (general obese group, n=1 000) who were admitted to the Sixth Afliated Hospital of Sun Yat-sen University between July 2019 and June 2025 by retrospective study. Body composition was assessed using the InBody S10 body composition analyzer, relevant hematological indicators of the two groups were collected, and dietary intake was evaluated usinga Food Frequency Questionnaire. Statistical analyses were performed by independent sample t-test, multiple linear regression analysis and Pearson correlation analysis. Result The extracellular water ratio of patients in the PCOS obese group was significantly higher than that in the general obese group (0.39±0.02 vs 0.37±0.02, t=15.321, P<0.001), while the phase angle of each frequency band was significantly lower than that in the general obese group (4.81°± 0.64°vs 5.35°±0.71°, t=-12.452, P<0.001); the body fat rate and visceral fat area of patients in the PCOS obese group were higher than those in the general obese group [(33.24±5.12)% vs (30.58±4.83)%, (85.61±25.32) cm2 vs (72.41±22.12) cm2, with t values of 9.215, 9.871, respectively, all P<0.001]; skeletal muscle mass and basal metabolic rate were significantly lower than those in the general obese group [(21.54±3.27) kg vs (23.81±3.59) kg, (1 256.00±187.00) kcal vs (1 354.00±203.00) kcal, with t values of -12.343, -8.761, respectively, all P<0.001]. Compared with the general obese group, patients in the PCOS obse group exhibited a more pronounced nutritional imbalance, characterized by significantly lower protein intake (15.27%±3.14% vs 17.62%±3.44%, t=-12.451, P<0.001), reduced dietary fiber consumption [(12.53±4.31) g/d vs (14.82±5.14) g/d, t=-7.893, P<0.001], a lower proportion of energy derived from fat [(26.52±5.31) % vs (30.01±5.84) %, t=-10.212, P<0.001], and a higher relative energy contribution from carbohydrates [(58.31%±6.24% vs 52.41%±5.82%, t=15.322, P<0.001]. Conclusion Compared with patients with general obese, obese patients with PCOS exhibit more pronounced abnormalities in body composition, unbalanced dietary structure, highlighting the need for optimized and targeted clinical strategies.
付雯雯 张丽娜 谢凤梅 等. 多囊卵巢综合征肥胖患者与普通肥胖患者营养代谢及人体成分差异比较[J]. 发育医学电子杂志, 2025, 13(6): 412-418.
Fu Wenwen, Zhang Li'na, Xie Fengmei, et al. Comparative of nutritional metabolism and body composition differences between obese patients with polycystic ovary syndrome and general obese patients. Journal of Developmental Medicine(Electronic Version), 2025, 13(6): 412-418.
2025, Vol. 13 
