Journal of Developmental Medicine(Electronic Version)  2023, Vol. 11 Issue (1): 19-24 DOI: 10.3969/j.issn.2095-5340.2023.01.004 |
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| Analysis of treatment of extremely premature infants with gestational age <26 weeks in single-center |
| Han Tao, Xu Aiping, Liu Changgen, et al
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(1. BeijingKey Laboratory of Pediatric Organ Failure, National Engineering Laboratory for Birth Defects Preventionand Control of Key Technology, Institute of Pediatrics, the Seventh Medical Center of PLA General Hospital,Faculty of Pediatrics, the Chinese PLA General Hospital, Beijing 100700, China; 2. Department of Pediatrics,Quzhou County Hospital, Hebei, Handan 057250, China)
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Abstract 【Abstract】 Objective To investigate the treatment and outcome of extremely preterm infant(EPI) with gestational age <26 weeks. Method From January 2018 to November 2022, EPIs with
gestational age <26 weeks in neonatal intensive care unit (NICU), Department of Pediatrics, the Chinese
PLA General Hospital were included in the study. The medical records during hospitalization were collected
through hospitalization registration records and electronic medical records, and the gestational age, birth
hospital, periventricular -intraventricular hemorrhage (PIVH) and outcome of the infants were recorded by
retrospective analysis. The annual number of EPIs with gestational age <26 weeks treated and their proportionin the annual number of EPIs were counted, and the incidence of severe PIVH and the cure or improvementrate were analyzed. Result From January 2018 to November 2022, the proportion of EPIs with gestationalage <26 weeks in the total number of EPIs admitted was as follows: 19.9% (38/191), 20.0% (36/180), 15.6%(14/90), 25.5% (26/102) and 27.1% (29/107). Except for 2020, the number of EPIs with gestational age < 26 weeksincreased year by year. The number of EPIs with gestational age <26 weeks born in Department of Obstetricsof this Hospital increased respectively, accounting for 0.0% (0/38), 5.6% (2/36), 14.3% (2/14), 15.4% (4/26)and 41.4% (12/29) of the annual number of EPIs with gestational age <26 weeks. Four and 12 cases of EPIs weretransferred prenatally. Among each year the proportion of EPIs with severe PIVH at gestational age <26 weekswas 29.0% (11/38), 36.1% (13/36), 28.6% (4/14), 34.6% (9/26) and 27.6% (8/29), respectively. The cure orimprovement rate of EPIs with gestational age <26 weeks from 2018 to 2022 were 76.3% (29/38), 55.6%(20/36), 71.4% (10/14), 57.7% (15/26) and 65.5% (19/29) respectively. Compared with other years, therewas a significant increase in EPIs at 23 weeks in 2022, but the overall number of treatment abandonment anddeath was significantly reduced, and the rate of cure improvement was increased. Conclusion From January2018 to November 2022, the proportion of EPIs with gestational age <26 weeks in the total number of EPIs in
Faculty of Pediatrics, the Chinese PLA General Hospital increased gradually, but the incidence with severe PIVHdoes not change significantly. Compared with previous years, the treatment of EPIs at 23 weeks gestational age ismore active in 2022, and the recovery rate increases.
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Received: 06 December 2022
Published: 30 January 2023
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