Journal of Developmental Medicine(Electronic Version)  2023, Vol. 11 Issue (2): 92-98 DOI: 10.3969/j.issn.2095-5340.2023.02.002 |
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| Meta-analysis of the clinical efficacy of bronchoalveolar lavage in the treatment of children with lobar pneumonia |
| Wang Wenyuan, Zhao Qijun, Wang Shuying,et al
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(Pediatric RespiratoryDepartment II, Gansu Provincial Maternity and Child-Care Hospital/ Central Hospital in Gansu Province,Gansu, Lanzhou 730070, China
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Abstract 【Abstract】 Objective To evaluate the clinical effect of bronchoalveolar lavage (BAL) on children with
lobar pneumonia. Method English literature databases: PubMed, EMBASE, The Cochrane Library,
Web of Science and Chinese literature database: Chinese National Knowledge Infrastructure (CNKI),
China Science Periodical Database (Wanfang Data), China Biology Medicine (CBM), China Science and
Technology Journal Database (VIP) were searched by computer. The literatures of randomized controlled
trial related to BAL in the treatment of children with lobar pneumonia from self-built database to February
3, 2020 were adopted in this study. The Cochrane risk bias assessment tool built into the software RevMan
5.4 provided by the Cochrane Collaboration was used to evaluate the quality of the included literatures.
The software Revman 5.4 was used for statistical analysis. Result Twenty-four studies were included,total 1 129 in the experimental (conventional treatment combined with BAL) group and 1 122 in the control(conventional treatment) group. The effective rate of conventional treatment combined with BAL group washigher than that in the conventional treatment group [OR=3.76, 95%CI: 2.65-5.31, P<0.05, I2=0], the timeof fever was shorter [MD=-2.43, 95%CI:-2.63--2.22, P<0.05, I2=91%], the time of cough disappeared wasshorter [MD=-3.97, 95%CI:-4.96--2.97, P<0.05, I2=99%], the time of rale disappearance was shorter [MD=-3.21, 95%CI: -3.66--2.77, P<0.05, I2=98%], the time of hospitalization was shorter [MD=-3.91, 95%CI: -4.27--3.55, P<0.05, I2=62%], the time of pulmonary shadow disappearance was faster [MD=-2.41, 95%CI: -3.01--1.84, P<0.05, I2=92%], the complications were fewer [OR=0.34, 95%CI: 0.19-0.62, P<0.05, I2=0]. Funnel plot analysis was conducted on the included literatures including treatment effectiveness, fever time, cough disappearance time, rale disappearance time, the time of hospitalization and the results showed that publication bias were small. Conclusion Conventional treatment combined with BAL in the treatment of children with lobar pneumonia can achieve better clinical efficacy and benefits.
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Received: 09 June 2022
Published: 31 March 2023
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