Journal of Developmental Medicine(Electronic Version)  2024, Vol. 12 Issue (4): 296-301,308 DOI: 10.3969/j.issn.2095-5340.2024.04.009 |
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| Research progress on factors related to the pathogenesis of bronchopulmonary dysplasia inpremature infants |
| Chen Huihui, Li Qiuping, Bian Jiaxin, et al
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(1.Screening and Diagnostic R and D Center, NationalEngineering Laboratory for Key Technology of Birth Defect Control and Prevention, Zhejiang, Hangzhou310007, China; 2.Department of Neonatology, the Seventh Medical Center of Chinese PLA General Hospital,Beijing 100700, China)
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Abstract 【Abstract】Bronchopulmonary dysplasia (BPD) is one of the most common diseases of preterm infants.
Children with BPD not only exhibited impaired lung function, poor exercise ability and airway hyper
reactivity, but also long-term complications. With the introduction of high-throughput sequencing technologyand the continuous development of molecular biology, although its pathogenesis has not been fullyunderstood, the survival rate of children with BPD has been significantly improved. A deeper understandingof the occurrence and development of BPD in the preterm infants was helpful for the treatment and nursing ofBPD. In this paper, the research progress of BPD related factors was reviewed from three aspects, includingpulmonary endothelial vascular development, pulmonary inflammatory response and pulmonary alveoliformation, which was advantageous to explain the genetic mechanism of BPD
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Received: 14 January 2023
Published: 31 July 2024
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