Journal of Developmental Medicine(Electronic Version)  2013, Vol. 1 Issue (3): 140-143 DOI: |
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| Establishment and clinical application of fluorescence in situ hybridization |
| JIANG Shu-fang,GA0 Zhi-ying,LU Yah-ping, et al
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| Department of Obstetrics and Gynecology,Clinical Division ofSurger；Chinese PLA General Hospital,Beijing 100853,China |
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Abstract 【Abstract】objectives To establish the method of fluorescence in situ hybridization，and evaluate the clinical significance in prenatal diagnosis．Methods Amniocytes or blood cells were obtained and processed，and FISH were performed with a panel of specific probes to detect abnormalities of chromosome 21，18，13，X，Y．Results It WaS considered as normal male or female that the fluorescence signals were observed in more than 90％cells．5 cases of Down syndrome，2 cases of transom 1 8 and 1 case of sex chromosomal abnormality were detected in 136 cases and test reports were sent in 72 hours．Conclusion FISH has important value in rapid prenatal diagnosis．
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Received: 15 February 2013
Published: 06 September 2019
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