Journal of Developmental Medicine(Electronic Version)  2023, Vol. 11 Issue (5): 371-376 DOI: 10.3969/j.issn.2095-5340.2023.05.008 |
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| Study on the correlation between amniotic fluid contamination and neonatal hypoxicischemic encephalopathy and the expression levels of serum Tau protein and S100B |
| Lyu Hongyan, Liu Fang, Wang Qiuli, et al
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(1.Department of Neonatology,Handan Maternal and Child Health Care Hospital, Hebei, Handan 056002, China; 2. Department of Pediatrics,the 980th Hospital of the PLA Joint Logistics Support Force, Hebei, Shijiazhuang 050082, China)
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Abstract 【Abstract】 Objective To investigate the correlation between amniotic fluid contamination and
neonatal hypoxic-ischemic encephalopathy (HIE) and the expression levels of serum Tau protein and
Sl00B. Method A total of 75 neonates with moderate to severe HIE admitted to the Neonatal Intensive
Care Unit (NICU), Handan Maternal and Child Health Care Hospital from August 2018 to August 2022 were
included in the HIE group (31 cases of moderate and 44 cases of severe). A total of 35 normal healthy full-
term newborns born in the Department of Obstetrics at the same period were included in the control group.According to the degree of amniotic fluid contamination, the children were divided into normal amnioticgroup and amniotic fluid contamination group of Ⅰ, Ⅱ and Ⅲ degrees. Amniotic fluid contamination andserum Tau protein and S100B expression levels were compared among all groups. The statistical methodsperformed by t-test, Student-Newman-Keuls test, χ2 test or Fisher exact probability method. Result Theproportion of natural vaginal delivery in the HIE group was lower than that in the control group [36.0% (27/75)vs 57.1% (20/35)], and the 5 min Apgar score of neonates in the HIE group was lower than that in the controlgroup [(3.5±1.4) vs (8.5±1.0) points], with statistical significance (all P<0.05). Of the 75 HIE infants, 20cases (26.7%) had normal amniotic fluid, 13 cases (17.3%) had grade I amniotic fluid contamination, 10cases (13.3%) had grade Ⅱ amniotic fluid contamination, and 32 cases (42.7%) had grade Ⅲ amniotic fluidcontamination. The proportion of grade Ⅲ amniotic fluid contamination in children with severe HIE washigher than that in children with moderate HIE, and the difference was statistically significant [59.1% (26/44)vs 19.4% (6/31), P<0.05]. The levels of serum Tau protein and S100B in moderate and severe HIE groupswere significantly higher than those in the control group (P<0.05). The levels of serum Tau protein and S100Bin severe HIE group were significantly higher than those in moderate HIE group, and the differences werestatistically significant (all P<0.05). The levels of serum Tau protein and S100B in HIE group with normalamniotic fluid and amniotic fluid contamination in Ⅰ, Ⅱ and Ⅲ degrees were significantly higher than thosein the control group, and the differences were statistically significant (P<0.05). The levels of serum Tauprotein and S100B in grade Ⅲ amniotic fluid contaminated HIE group were significantly higher than those innormal amniotic fluid HIE group and grade Ⅰ amniotic fluid contaminated HIE group, and the differences werestatistically significant (all P<0.05). Conclusion Amniotic fluid contamination is closely related to neonates with HIE. Among children with severe HIE, the proportion of grade Ⅲ amniotic fluid contamination is higher, thelevels of serum Tau protein and S100B are also higher, and the degree of brain injury is more serious.
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Received: 23 April 2023
Published: 27 September 2023
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