Journal of Developmental Medicine(Electronic Version)  2024, Vol. 12 Issue (3): 187-192 DOI: 10.3969/j.issn.2095-5340.2024.03.005 |
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| Analysis of curative effect of ozone hydrotherapy in children with atopic dermatit |
| Xie Hongxia, Huo Wenqian, Chen Danyang, et al
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(Department of Dermatology, HebeiIntegrated Traditional Chinese and Western Medicine Children's Hospital, Hebei, Shijiazhuang 050000,China)
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Abstract 【Abstract】 Objective To explore therapeutic effect of ozone hydrotherapy in children with atopic
dermatitis and the changes of inflammatory factors. Method A total of 100 children with atopic
dermatitis in Hebei Integrated Traditional Chinese and Western Medicine Children's Hospital from April
2019 to April 2021 were selected and divided into control group (n=50) and observation group (n=50)
according to the random number table method. Children in the control group were given desloratadine
dry suspension orally, desonide cream for external use, and then given jojoba oil baby lotion children in
the observation group were treated with ozone hydrotherapy on the basis of control group. The levels of
serum inflammatory factors interleukin-17 (IL-17), interleukin-13 (IL-13), and eczema area and severity
index (EASI) score, scoring atopic dermatitis index (SCORAD)，quality of life, clinical efficacy and
security were compared between the two groups. The statistical methods performed by Independentsample t-test, paired sample t-test, and χ2-test. Result After treatment, serum IL-17 level [(23.8±2.0) ng/Lvs (26.9±2.5) ng/L, t=6.847], IL-13 level [(26.8±2.1) ng/L vs (30.6±2.6) ng/L, t=8.040], SCORAD score[(23.0±1.5) points vs (30.3±2.0) points, t=20.648], EASI score [(2.1±0.8) points vs (3.8±0.9) points,t=9.983], the children's dermatology life quality index (CDLQI) score [(6.1±1.4) points vs (9.6±1.8) points,t=8.470], the infants' dermatology life quality index (IDQOL) scores [(6.8±1.3) points vs (10.8±1.8) points,t=7.947] were lower in observation group than those in control group (all P<0.001). After treatment, serumL-17 level, IL-13 level, SCORAD score, EASI score, CDLQI score and IDQOL score in observation groupand control group were significantly lower than before treatment, with statistical significance (all P<0.05).The effective rate of observation group was higher than that of control group [94.0% (47/50) vs 76.0% (38/50),χ2=5.020, P=0.025). Conclusion Ozone hydrotherapy for children with atopic dermatitis can effectivelyimprove the clinical symptoms and sleep quality of patients, reduce itching and inflammatory reactions, and improve the quality of life, which is safe and effective.
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Received: 07 March 2023
Published: 31 May 2024
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