Journal of Developmental Medicine(Electronic Version)  2024, Vol. 12 Issue (4): 302-308 DOI: 10.3969/j.issn.2095-5340.2024.04.010 |
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| Research progress on the role of oxidative stress signaling pathways in pain pathogenesis ofchronic prostatitis/chronic pelvic pain syndrome |
| Zhang Qiang, Su Xuzhen, Xiang Ruijun, et al
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(1. School of ClinicalMedicine, Gansu University of Chinese Medicine, Gansu, Lanzhou 730030, China; 2. Department of Urology, the 940 Hospital of Joint Logistics Support Force of Chinese PLA, Gansu, Lanzhou 730050, China)
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Abstract 【Abstract】Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common urological disease.
In the research progress of CP/CPPS treatment, it has been found that the regulation of oxidative stress andinflammation response through nuclear factor kappa-B (NF-κB), nuclear factor erythroid-2 related factor2 (Nrf2), mitogen-activated protein kinase (MAPK) and other signaling pathways can reduce CP/CPPS
symptoms. In recent years, it has been found that the regulation of forkhead box O (FOXO), silent informationregulator 1(Sirt1), extracellular signal-regulated kinase(Erk), ras homolog gene family member A(RhoA)/Rho-associated protein kinase 1(ROCK1) and other signaling pathways can relieve prostatic inflammationand pelvic pain, providing a new target for CP/CPPS treatment.
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Received: 03 February 2023
Published: 31 July 2024
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