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Abstract
Autism spectrum disorder (ASD) is a neurodevelopmental disorder, and sleep disorders are a common comorbidity in children with ASD, affecting their emotions, behavior, and cognition, and imposing a heavy burden on their families and society. Melatonin is an endogenous hormone synthesized and secreted by the pineal gland of the brain through the suprachiasmatic nucleus. Numerous experiments have shown
that melatonin can improve sleep disorders in children with ASD, with minimal side effects. Therefore,
melatonin is considered to have good prospects in treating sleep disorders in children with ASD. The paper
reviews relevant literature at home and abroad in recent years to discuss the mechanism and treatment effect of melatonin for sleep disorders in children with ASD.
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