Journal of Developmental Medicine(Electronic Version)  2015, Vol. 3 Issue (4): 224-229 DOI: |
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| Comparison of pregnancy outcome of PCOS patients who has been receiving ovulation induction by HMG combined with different dosage of letrozole#br# |
| XIAO Nan, ZHAO Hua, KONG Ping-ping,et al
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| XIAO Nan, ZHAO Hua, KONG Ping-ping, JIN Lei(Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, Wuhan, 430030, China) |
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Abstract Objective To compare the pregnancy outcome of patients with PCOS who has been receiving ovulation induction by HMG combined with different doses of LE, and to summarize the best dosage of LE in the combined ovulation induction scheme. Method This is a prospective and randomized cotrolled study. 142 PCOS patients who showed no dominant follicular after the ovulation of LE were randomly included by using the random number table, and were divided into group LE 2.5 mg (n=70) and group LE 5.0 mg (n=72). The number of dominant follicles, E2 level on the day of HCG injection, endometrial thickness on the day of HCG injection, HMG usage and clinical outcome related indicators were copared. Results There is no significant difference in age, duration of infertility, BMI, D3 FSH, D3 E2 and D3 endometrial thickness between the two groups(P>0.05). During the process of ovulation induction, there is no significant difference in the number of 14-18mm follicles, the rate of ovulation , endometrial thickness on the day of HCG injection, the rate of biochemical pregnancy, the rate of multiple pregnancy, the rate of miscarriage, the rate of cancelled cycle and the rate of OHSS between the two groups (P>0.05). ≥18mm follicles, E2 levels on the day of HCG injection, dosage of HMG and the days of using HMG is higher in group LE 5.0 mg than group LE 2.5 mg, and the difference is statistically significant(P<0.05). Compared to group LE 2.5 mg, group LE 5.0 mg shows an increasing trend in the rate of clinical pregnancy, although the difference is not statistically significant(P>0.05). Conclusions PCOS patients who showed no dominant follicular after the ovulation of LE only should receive ovulation induction by HMG combined LE, and the appropriate choice of the dosage of LE should be 5.0 mg/d rather than 2.5 mg/d.
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Received: 10 December 2014
Published: 22 March 2018
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