Journal of Developmental Medicine(Electronic Version)  2024, Vol. 12 Issue (3): 161-165 DOI: 10.3969/j.issn.2095-5340.2024.03.001 |
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| Outcome of neonates delivered by group B Streptococcus positive pregnant women andanalysis of early inflammatory indicators detection |
| Li Yurui, Zhang Xuefeng, He Xiyu, et al
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Department of Pediatrics, the Fifth MedicalCenter of PLA General Hospital, Beijing 100039, China)
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Abstract 【Abstract】 Objective To analyze the outcome of neonates delivered by group B Streptococcus (GBS)
positive pregnant women and the clinical application value of early inflammatory indicators detection.
Method A total of 135 high-risk neonates delivered by GBS positive pregnant women admitted to the FifthMedical Center of the PLA General Hospital from October 2017 to October 2021 were selected as the studyobjects, and divided into the antibiotic group (n=77 ) and the control group (n=58 ) according to whether thepregnant mothers used antibiotics before delivery. The maternal condition, general condition of neonates, therate of pathological jaundice, white blood cell (WBC) count, C-reactive protein (CRP) and procalcitonin (PCT)levels at different time points were compared between the two groups. The clinical application value of WBC,CRP and PCT in different time points was analyzed by receiver operating characteristic (ROC) curve. Thestatistical methods performed by independent sample t-test, χ2 test and rank sum test. Result The abnormal rate of neonatal inflammatory indicators in the antibiotic group were significantly lower than those in thecontrol group [26.0% (20/77) vs 48.3% (28/55), χ2=6.311, P=0.012]. There were no significant differences inthe delivery method, amniotic fluid contamination rate, premature rupture rate of membranes and incidence of pathological jaundice between the two groups (all P>0.05). The levels of CRP in the antibiotic group at6 h and 24 h was lower than that in the control group [0.2 (0.1, 0.3) mg/L vs 0.2 (0.1, 0.4) mg/L, 2.3 (1.0,6.0) mg/L vs 4.0 (2.8, 10.5) mg/L, t=-3.137, -3.010, all P<0.05]. Among the 135 high-risk neonates, 2 cases(1.5%) developed early onset GBS septicemia. 48 cases (35.6%) with abnormal inflammatory indicators,and they were hospitalized for (6.3±1.3) days on average, and were cured and discharged from hospital.The combined detection of WBC and CRP at 24 h postnatal was the most significant for neonatal infection,and the area under the curve (AUC) was 0.882. Conclusion Prophylactic treatment with antibiotics forGBS positive pregnant women before delivery can reduce the incidence of neonatal infection. The combineddetection of WBC and CRP at 24 h postnatal is of great significance for early detection of neonatal infection.
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Received: 14 August 2023
Published: 31 May 2024
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