发育医学电子杂志  2020, Vol. 8 Issue (4): 297-303 DOI: 10.3969/j.issn.2095-5340.2020.04.002 |
|
发育基础
专题笔谈
|
|
|
|
|
|
哺乳动物合子基因组激活调控机制
|
张加明 孔庆然
|
温州医科大学 检验医学与生命科学学院 检验医学教育部重点 实验室，浙江 温州 325035
|
|
Regulatory mechanisms on zygotic genome activation in mammals
|
| Zhang Jiaming, Kong Qingran |
|
|
|
摘要
哺乳动物早期胚胎发育是指卵母细胞受精并发育到囊胚的整个过程，雌雄配子在受精后发生迅速重编程形成全能性细胞，重获分化为个体各种类型细胞的潜能［1-5］ 。早期胚胎基因组处于沉默状态，前几次卵裂是由储存在卵母细胞中的母源因子所调控的，直至合子基因组激活（zygotic genomeactivation，ZGA），胚胎发育的调控由母源因子向胚胎基因组转换，此过程称为母胚转换（maternalzygote transition，MZT）［6-9］。ZGA 对于个体发育具有重要意义，是胚胎自身基因组调控个体发育的动力，其发生机制的探究对辅助生殖与疾病治疗具有重大意义。
|
|
| 关键词:
早期胚胎发育')" href="#">
早期胚胎发育
合子基因组激活
染色体重塑
转录因子
|
|
收稿日期: 2020-05-06
发布日期: 2020-11-03
|
| 基金资助:
浙江省医学技术国家重点研究和一流学科（A 类）资助（437601607）
|
|
通讯作者:
孔庆然
E-mail: kqr721726@163.com
|
| [1] |
GAO Xiao-hui, MAO Jian. Clinical features of non-oliguric hyperkalemia in extremely low birth weight infants[J]. Journal of Developmental Medicine(Electronic Version), 0, (): 152
. |
| [2] |
Society of Neonatologist, Chinese Medical Doctor Association. Consensus recommendations on the prevention and early management of respiratory distress syndrome in preterm infants[J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 129
-131
. |
| [3] |
Professional Committee of Respiratory, Society of Neonatologist, Chinese Medical Doctor Association. Clinical application recommendations for heated humidified high flow nasal cannula[J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 132
-135
. |
| [4] |
YAN Jun, ZHU Xing-wang, SHI Yuan. Application progress of noninvasive ventilate technique for premature infants[J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 136
-140
. |
| [5] |
GU Min-fang, YANG Chuan-zhong. Progress of intrapartum resuscitation for premature infants[J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 141
-145
. |
| [6] |
LIU Shu-hua, SHEN Yue-bo, LIU Cui-qing, MA Li. The efficacy of pulmonary surfactant for pulmonary function in premature tension pneumothorax[J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 146
-151
. |
| [7] |
GAO Xiao-hui, MAO Jian. Clinical features of non-oliguric hyperkalemia in extremely low birth weight infants[J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 152
-158
. |
| [8] |
XIA Yao-fang, YANG Juan , TIAN Bao-li, et al. Value of amplitude-integrated electroencephalography in monitoring acute period of neonatal bilirubin encephalopathy and prognostic assessment[J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 159
-163
. |
| [9] |
WANG Li-rong, SUN Xiao-yan, ZHU Ruo-xin, et al. Epidemiological investigation and analysis of women aged 40-55 years old with osteoporosis in Gansu province[J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 164
-167
. |
| [10] |
CHEN Ru-yue, SHEN Yun-yan, CHEN Qing , et al. Five cases about Henoch-Schönlein purpura complicated with central nervous system injury in children and literatures review[J]. Journal of Developmental Medicine(Electronic Version), 2017, 5(3): 168
-171
. |
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
