An cohort study of change law of serum alkaline phosphatase in pregnant women with different gestation
Wu Liting, Xue Jia, Li Shimeng, et al
Key Laboratory of Congenital Malformation of Ministry of Health Shengjing Hospital Affiliated to China Medical University, Liaoning, Shenyang 110004, China
【Abstract】 Objective To explore the longitudinal changes of serum alkaline phosphates (ALP) in the
whole pregnancy of pregnant women , and provide relevant basis for determining the normal reference range of serum ALP in different gestational weeks and its changes in adverse pregnancy outcomes. Methods Based on prospective cohort study, 213 pregnant women within 7 weeks were recruited from 2017 to 2018 in Shengjing Hospital. The fasting venous blood were collected and the serum ALP were detected every 4 weeks, the change characteristics of ALP were analysed by replicate measures analysis of variance (ANOVA) , and the pregnancy outcome was tracked. 184 healthy pregnant women completed follow-up, and 122 pregnant women with normal pregnancy outcome and complete data(normal group), 36 pregnant women with adverse pregnancyoutcome(adverse pregnancy group), they were finally included in this study. The serum ALP change of the pregnant women with different gestational age was analysed. Results The serum ALP had no statistically significant difference between the two groups （P>0.05）. In normal group, it showed a downward trend in the early pregnancy at 5-15 weeks, and increased rapidly with the gestational age after 15 weeks, reaching thepeak before delivery. The reference range of ALP in 5-27 weeks was lower than the normal reference interval,and its cut off value was close to the upper limit of the normal; while that in 37-39 weeks was significantly higher, its cut off value were 3 times of the upper limit of the normal reference. Conclusions Serum ALP level in whole pregnancy of normal pregnant women showed regular changes. Different normal reference valuestandards should be established according to different pregnancy periods, and regular detection of the changesduring pregnancy has certain guiding significance in predicting the existence of adverse pregnancy outcomes.
伍丽婷 薛佳 李诗萌 袁正伟. 孕妇不同孕周血清碱性磷酸酶变化规律的队列研究[J]. 发育医学电子杂志, 2021, 9(1): 43-48.
Wu Liting, Xue Jia, Li Shimeng, et al. An cohort study of change law of serum alkaline phosphatase in pregnant women with different gestation. Journal of Developmental Medicine(Electronic Version), 2021, 9(1): 43-48.
2021, Vol. 9 
