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发育医学电子杂志  2023, Vol. 11 Issue (6): 434-440    DOI: 10.3969/j.issn.2095-5340.2023.06.006
  生长发育   论著 |
孟鲁司特钠治疗汉族儿童支气管哮喘疗效与ABCC1、SLCO2B1 基因单核苷酸多态性的相关性研究
石慧莉 杨一民 王珊珊 陈茜 洪菲萍 黄永莲 李溦
(1. 福建中医药大学附属厦门市中医院 儿科,福建 厦门 361009;2. 厦门弘爱妇产医院 新生儿科,福建 厦门 361000)
Correlation between single nucleotide polymorphisms of ABCC1, SLCO2B1 genes andmontelukast sodium in the treatment of bronchial asthma in children of Han nationality
Shi Huili , Yang Yimin, Wang Shanshan, et al
(1.Department of Pediatrics, Xiamen Hospital of Traditional Chinese Medicine Affiliated to Fujian Universityof Chinese Medicine, Fujian, Xiamen 361009, China; 2.Department of Neonatology, Xiamen HongaiMaternity Hospital, Fujian, Xiamen 361000, China)
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摘要 【摘要】 目的  探讨白三烯受体拮抗剂(leukotriene receptor antagonists,LTRA)与ATP 结合盒亚家
族C1(ATP-binding cassette sub-family C member 1,ABCC1)基因rs119774 位点、溶质载体有机阴离
子转运蛋白家族成员2B1 (solute carrier organic anion transporter family member 2B1,SLCO2B1)基因
rs12422149 位点的单核苷酸多态性(single nucleotide polymorphism,SNP)治疗汉族儿童支气管哮喘疗
效的相关性。 方法 选取2019 年4 月至2021 年12 月于福建中医药大学附属厦门市中医院就诊的
4~13 岁汉族支气管哮喘患儿100 例为研究对象,采用一代测序法对患儿的ABCC1 基因rs119774 位
点、SLCO2B1 基因rs12422149 位点进行检测,分析比较2 个位点的SNP 分布情况。入组患儿均应用
LTRA 进行治疗,分别于治疗前与治疗12 周时进行肺通气功能及脉冲震荡功能检测,并评估临床症状
控制水平,分析患儿疗效与SNP 的相关性。统计学方法采用t 检验、χ2 检验。 结果  治疗前与治
疗12 周后,ABCC1 基因rs119774 位点CC 型哮喘患儿应用孟鲁司特钠第1 秒用力呼气容积(forced
expiratory volume in the first second,FEV1)[(87.0±16.5)与(93.2±15.1)L,t=-2.071,P=0.038]、峰值呼气流速(peak expiratory flow, PEF)[ (77.1±16.9)与(86.5±16.6)L/s,t=-3.233,P=0.001]和 25% 肺活量的呼气流速(forced expiratory flow 25,FEF25)[(69.6±18.8)与(78.1±19.9)L/s,t=-1.985,P=0.047]均有明显提高,脉冲震荡各项指标显著改善(P<0.05)。治疗后SLCO2B1 基因rs12422149 位点 AA 型肺功能指标PEF 高于治疗前[(79.0±16.0)与(93.0±9.4)L/s,t=-2.547,P=0.011),治疗后GG 型肺功能各指标显著高于治疗前(P<0.05)。ABCC1 治疗前后控制率[59% (59/100)与78% (78/100), 78% (78/100),χ2=20.964,P<0.001];治疗前后SLCO2B1基因rs119774位点AA型、AG 型、GG 型的控制率分别为[ 59%(59/100)与78%(78/100),78%(78/100),χ2=20.964,P<0.001]、[53%(8/15)与80%(12/15),93%(14/15)χ2=12.786,P=0.002]与[56%(23/41)与78%(32/41),78%(32/41),χ2=6.583,P=0.037]与[73%(32/44)与77%(34/44),73%(32/44)],χ2=6.471,P=0.039],均显著改善。 结论 LTRA 治疗汉族支气管哮喘患儿与ABCC1、SLCO2B1 基因SNP 的效果存在相关性。
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关键词:  支气管哮喘  ABCC1 基因  SLCO2B1 基因  单核苷酸多态性  白三烯受体拮抗剂  汉族儿童    
Abstract: 【Abstract】 Objective To evaluate the correlation between leukotriene receptor antagonist(LTRA) and
single nucleotide polymorphism (SNP) of ATP-binding cassette sub-family C member 1 (ABCC1) genes and
solute carrier organic anion transporter family member 2B1(SLCO2B1)genes in the treatment of bronchial
asthma in children of Han nationality. Method A total of 100 cases with bronchial asthma of Han
nationality aged 4-13 years who were treated in Xiamen Hospital of Traditional Chinese Medicine Affiliated toFujian University of Chinese Medicine from April 2019 to December 2021 were selected as the study objects. Thers119774 locus of ABCC1 gene and rs12422149 locus of SLCO2B1 gene of the cases were detected by generationsequencing, and the SNP distribution of the two sites was analyzed and compared. All enrolled cases weretreated with LTRA. Pulmonary ventilation function and pulse shock lung function were detected and asthmasymptom control level was evaluated before and after 12 weeks of treatment, and the correlation betweenSNP and efficacy was analyzed. Statistical methods were used by t test and χ2 test.  Result Before and12 weeks after treatment, cases with CC asthma at rs119774 locus of ABCC1 gene were treated with montelukastsodium forced expiratory volume in the first second (FEV1) [(87.0±16.5) vs (93.2±15.1) L, t=-2.071,P=0.038], peak expiratory flow (PEF) [(77.1±16.9) vs (86.5±16.6) L/s, t=-3.233, P=0.001]and forced expiratory flow 25 (FEF25) of 25% vital capacity [(69.6±18.8) vs (78.1±19.9) L/s,t=-1.985, P=0.047] were significantly increased. The indicators of pulse shock were significantlyimproved (P<0.05). The pulmonary function index PEF of SLCO2B1 gene rs12422149 AA typeafter treatment was higher than that before treatment [(79.0±16.0) vs (93.0±9.4) L/s, t=-2.547,P=0.011]. The lung function indexes of GG type after treatment were significantly higher than those beforetreatment (P<0.05). Control rate before and after treatment with ABCC1 [59% (59/100) vs 78% (78/100),78% (78/100), χ2=20.964, P<0.001]; control rates of AA, AG and GG type at rs119774 of SLCO2B1 gene beforeand after treatment [53% (8/15) vs 80% (12/15), 93% (14/15), χ2=12.786, P=0.002] and [56% (23/41) vs 78%(32/41), 78% (32/41), χ2=6.583, P=0.037] and [73% (32/44) vs 77% (34/44), 73% (32/44)], χ2=6.471, P=0.039]were significantly improved. Conclusion There is a correlation between the effect of LTRA on the SNP ofABCC1 and SLCO2B1 gene in children with bronchial asthma of Han nationality.
Key words:  Bronchial asthma    ABCC1 gene    SLCO2B1 gene    Single nucleotide polymorphism    Leukotriene receptor antagonist    The Han nationality children
收稿日期:  2022-10-28                     发布日期:  2023-11-29     
基金资助: 福建省科技厅引导性项目(2019D012)
通讯作者:  杨一民    E-mail:  yym216@126.com
引用本文:    
石慧莉 杨一民 王珊珊 陈茜 洪菲萍 黄永莲 李溦. 孟鲁司特钠治疗汉族儿童支气管哮喘疗效与ABCC1、SLCO2B1 基因单核苷酸多态性的相关性研究[J]. 发育医学电子杂志, 2023, 11(6): 434-440.
Shi Huili , Yang Yimin, Wang Shanshan, et al. Correlation between single nucleotide polymorphisms of ABCC1, SLCO2B1 genes andmontelukast sodium in the treatment of bronchial asthma in children of Han nationality. Journal of Developmental Medicine(Electronic Version), 2023, 11(6): 434-440.
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