Abstract: 【Abstract】 Objective To explore therapeutic effect of ozone hydrotherapy in children with atopic dermatitis and the changes of inflammatory factors. Method A total of 100 children with atopic dermatitis in Hebei Integrated Traditional Chinese and Western Medicine Children's Hospital from April 2019 to April 2021 were selected and divided into control group (n=50) and observation group (n=50) according to the random number table method. Children in the control group were given desloratadine dry suspension orally, desonide cream for external use, and then given jojoba oil baby lotion children in the observation group were treated with ozone hydrotherapy on the basis of control group. The levels of serum inflammatory factors interleukin-17 (IL-17), interleukin-13 (IL-13), and eczema area and severity index (EASI) score, scoring atopic dermatitis index (SCORAD)，quality of life, clinical efficacy and security were compared between the two groups. The statistical methods performed by Independentsample t-test, paired sample t-test, and χ2-test. Result After treatment, serum IL-17 level [(23.8±2.0) ng/Lvs (26.9±2.5) ng/L, t=6.847], IL-13 level [(26.8±2.1) ng/L vs (30.6±2.6) ng/L, t=8.040], SCORAD score[(23.0±1.5) points vs (30.3±2.0) points, t=20.648], EASI score [(2.1±0.8) points vs (3.8±0.9) points,t=9.983], the children's dermatology life quality index (CDLQI) score [(6.1±1.4) points vs (9.6±1.8) points,t=8.470], the infants' dermatology life quality index (IDQOL) scores [(6.8±1.3) points vs (10.8±1.8) points,t=7.947] were lower in observation group than those in control group (all P<0.001). After treatment, serumL-17 level, IL-13 level, SCORAD score, EASI score, CDLQI score and IDQOL score in observation groupand control group were significantly lower than before treatment, with statistical significance (all P<0.05).The effective rate of observation group was higher than that of control group [94.0% (47/50) vs 76.0% (38/50),χ2=5.020, P=0.025). Conclusion Ozone hydrotherapy for children with atopic dermatitis can effectivelyimprove the clinical symptoms and sleep quality of patients, reduce itching and inflammatory reactions, and improve the quality of life, which is safe and effective.
谢红霞 霍文倩 陈丹阳 盖田 田艳欣. 臭氧水疗治疗儿童特应性皮炎的疗效分析[J]. 发育医学电子杂志, 2024, 12(3): 187-192.
Xie Hongxia, Huo Wenqian, Chen Danyang, et al. Analysis of curative effect of ozone hydrotherapy in children with atopic dermatit. Journal of Developmental Medicine(Electronic Version), 2024, 12(3): 187-192.
2024, Vol. 12 
