精子DNA 碎片检测在男性不育症患者临床评估和治疗中的研究进展

doi:10.3969/j.issn.2095-5340.2024.04.012

发育医学电子杂志

2024, Vol. 12

Issue (4): 314-320 DOI: 10.3969/j.issn.2095-5340.2024.04.012

生殖胚胎综述

精子DNA 碎片检测在男性不育症患者临床评估和治疗中的研究进展

张耀东　郭舒筱　颜宏利

（1. 海军第九七一医院　检验科，山东　青岛　266071 ；2. 海军军医大学长海医院　生殖医学中心，上海　200433）

Research progress of sperm DNA fragmentation detection in clinical evaluation andtreatment of male infertility

Zhang Yaodong, Guo Shuxiao, Yan Hongli

(1.Department of Clinical Laboratory, the 971st Hospital ofPLA, Shandong, Qingdao 266071, China; 2.Department of Reproductive Medicine, Changhai Hospital, NavalMedical University, Shanghai 200433, China)

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摘要 【摘要】 近年来，我国人口呈现出生率降低和老龄化进程加快的国情，改善和提高男性生育力问题引发
社会关注。精子DNA 碎片指数（DNA fragmentation index，DFI）作为一种新的精子质量评价标志物，目
前广泛应用于临床不育症患者精液样本检测中。随着2023 年《精子DNA 碎片检测的临床专家共识》
发布，为精子DFI 应用于不育症患者临床评估和治疗提供了依据和标准。本文将对近年来国内外报道
的精子DFI 与辅助生殖技术（assisted reproductive technique，ART）治疗结局关系、精子DFI 与精子参数
一致性关系、精子DFI 检测方法评价等研究进行综述。

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关键词: 精子 DNA 碎片不育症妊娠

Abstract: 【Abstract】As the decreasing birth rate and accelerating aging process, the research on improving male
reproductive ability has taken extensive attention in recently years. As a new marker for sperm quality
evaluation, sperm DNA fragmentation index (DFI) has been increasingly used in semen samples detection ofmale infertility. With the publication of clinical expert consensus on sperm DNA fragmentation detection in2023, it provides the basis and standard for sperm DFI to clinical evaluation and treatment of male infertility.This review briefly summarizes the research progress on the relationship between sperm DFI and assistedreproductive technique (ART) treatment outcome, the consistency between sperm DFI and sperm parameters,and the evaluation of clinical sperm DFI detection methods in recent years.

Key words: Sperm DNA fragmentation Infertility Pregnancy

收稿日期: 2023-03-07 发布日期: 2024-07-31

基金资助: 青岛市医药卫生面上项目（2023-WJZD238）

通讯作者: 颜宏利 E-mail: hongliyan@smmu.edu.cn

引用本文:

张耀东　郭舒筱　颜宏利. 精子DNA 碎片检测在男性不育症患者临床评估和治疗中的研究进展[J]. 发育医学电子杂志, 2024, 12(4): 314-320.
Zhang Yaodong, Guo Shuxiao, Yan Hongli. Research progress of sperm DNA fragmentation detection in clinical evaluation andtreatment of male infertility. Journal of Developmental Medicine(Electronic Version), 2024, 12(4): 314-320.

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