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发育医学电子杂志  2022, Vol. 10 Issue (5): 330-339    DOI: 10.3969/j.issn.2095-5340.2022.05.002
  结构畸形   论著 |
泌尿系统发育相关研究现状及趋势的文献计量和可视化分析
赵丹 欧阳辰昕 敬鹏 何文飞 项涛 王城
1. 川北医学院附属医院 小儿外科,四川 南充 637000;2. 川北医学院 实验动物中心,四川 南充 
637000)
Bibliometric and visual analysis of current research status and trends related to urinary system development
Zhao Dan, Ouyang Chenxin, Jing Peng, et al
(1.Department of PediatricSurgery, Affiliated Hospital of North Sichuan Medical College, Sichuan, Nanchong 637000, China;2.Laboratory Animal Center, North Sichuan Medical College, Sichuan, Nanchong 637000, China)
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摘要 【摘要】 目的 对泌尿系统发育相关研究的现状及趋势进行文献计量研究和可视化分析。 方法 使用Web of Science 数据库核心合集,检索1990 至2020 年发表的泌尿系统发育相关的研究文献。应用文献计量学方法并结合R 语言中的Bibliometrix 包,对各年度发表的文献数量、期刊、第一作者及通信作者、国家、研究机构、研究领域、被引频次、关键词予以统计分析。应用VOSviewer 软件对文章的关键词进行可视化聚类,并进行研究主题的演进过程桑基图和关键词战略坐标图分析。 结果 共检索到4 064 篇文献,最终纳入1 594 篇。1990 至2010 年,平均每年发表(47.0±8.0)篇;2011 至2020 年发表数量上升,平均每年发表(60.6±5.9)篇。共有619 本期刊发表过泌尿系统发育相关的文献, 排名第 1 位的是 Journal of Urology( 81 篇)。以第一作者身份发表相关文献的学者中,发表文献数量最多的是Gattone V H 和Okada T(各5 篇)。以通信作者身份发表相关文献的学者中,发表文献数量最多的是Nishinakamura R、Okada T、Potter S S(各7 篇)。纳入文献来自55 个国家,排名前3 位的分别是美国(509 篇)、日本(163 篇)、中国(117 篇)。纳入文献来自1 758 家研究机构,排名第1 位的是美国匹兹堡大学(101 篇);中国医科大学(21 篇)排名第31 位。纳入文献共涉及93 个研究领域,绝大多数涉及泌尿学/ 肾病学,其次是细胞生物学和发育生物学。纳入文献的总被引频次达51 353 次,排名第1 位的文献(938 次)于1996 年发表。纳入文献共有6 968 个关键词,出现频次排名前5 位的关键词分别是表达(326 篇)、肾脏(163 篇)、小鼠(161 篇)、大鼠(147 篇)以及细胞(143 篇)。利用VOSviewer 软件可视化分析显示,研究主要集中在两大类:肾脏发育异常相关疾病、泌尿系统发育基因表达和形态形成。研究主题的演进过程桑基图显示,1990 至2020 年,泌尿系统发育基因表达依然是研究的热点和焦点。关键词战略坐标图分析显示,泌尿系统发育相关研究的热点和未来发展的趋势依然集中在基因表达上。 结论 目前国际上对泌尿系统发育相关研究呈上升趋势。未来将以细胞生物学和发育生物学领域为主导,继续深入探索基因表达调控机制,以期将成果应用于泌尿系统发育异常相关疾病研究和组织工程学。
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关键词:  泌尿系统发育  细胞生物学  发育生物学  文献计量学  聚类分析  可视化分析    
Abstract: Objective To conduct a bibliometric and visual analysis of the current status and trends of
international research on urinary system development. Method The core collection of the Web of Sciencedatabase was used to search the literatures on urinary system development published from 1990 to 2020.The bibliometric method was performed and the Bibliometrix package in R language was used to analyzethe number of documents published each year, journals, first authors and corresponding authors, countries,research institutions, research fields, citation frequencies, and keywords. The software VOSviewer wasapplied to visually cluster keywords. The Sankey diagram and the strategic coordinate chart of keywordswere analyzed for the evolution of the research themes. Result A total of 4 064 articles wereretrieved, and 1 594 articles related to the development of urinary system were finally included. From
1990 to 2010, an average of (47.0±8.0) articles were published every year. From 2011 to 2020, the numberof publications increased, with an average of (60.6±5.9) articles per year. Totally 619 journals publishedurinary system development related articles, among which Journal of Urology was top (81 articles). As thefirst author, the number of articles published by Gattone V H and Okada T was tied for the
first place ( 5 articles each), and so was the number of articles published by Nishinakamura R, Okada T
and Pot S S as the corresponding author (7 articles each). All the 1 594 articles were from 55 countries, among which theop three were the United States (509 articles), Japan (163 articles) and China (117 articles). All the 1 594 articles werefrom 1 758 institutions, among which the top was the University of Pittsburgh (101 articles). The number ofarticles published by China Medical University ranked 31st (21 articles). All the 1 594 articles were in 93 researchfields, and the top three research fields were urology & nephrology, cell biology and developmental biology.The included articles were cited 51 353 times in total, and the most frequently cited article (938 times) waspublished in 1996. A total of 6 968 keywords were included in the literature, and the top five keywordswere expression (326 articles), kidney (163 articles), mouse (161 articles), rat (147 articles) and cell(143 articles). Using VOSviewer software analysis, the research direction of urinary system developmentmainly focused on two parts: renal dysplasia related diseases, and gene expression and morphogenesisof urinary system development. According to the Sankey diagram, from 1990 to 2020, gene expressionin the development of the urinary system was still the focus of research. According to the strategiccoordinate chart of keywords, the future research trend would be focused on the gene expression. Conclusion The international interest in researches related to the development of the urinary system isuptrend. In the future, the res earches would be dominated by the fi elds of cell biology and developmentalbiology, and continue to explore the mechanism of gene expression regulation, hoping to apply theresults to the researches of diseases related to the abnormal development of the urinary system and tissueengineering.
Key words:  Development of urinary system    Cell biology    Developmental biology    Bibliometric    Clusteranalysis    Visual analysis
收稿日期:  2021-12-24                     发布日期:  2022-09-30     
基金资助: 四川省卫生健康委员会科研课题(20PJ147);南充市科技项目市校科技战略合作专项(19SXHZ0113)
通讯作者:  赵丹    E-mail:  Email:zd_5404@163.com
引用本文:    
赵丹 欧阳辰昕 敬鹏 何文飞 项涛 王城. 泌尿系统发育相关研究现状及趋势的文献计量和可视化分析[J]. 发育医学电子杂志, 2022, 10(5): 330-339.
Zhao Dan, Ouyang Chenxin, Jing Peng, et al. Bibliometric and visual analysis of current research status and trends related to urinary system development. Journal of Developmental Medicine(Electronic Version), 2022, 10(5): 330-339.
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[2] 张苇 辛子娟 张昭军 方向东. 单细胞转录组测序与人工智能在发育生物学中的应用[J]. 发育医学电子杂志, 2020, 8(1): 1-7.
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