发育医学电子杂志 Vol. 6 117-120
结构畸形
综述
蛋白质小泛素样修饰体化修饰对神经 发育和功能的影响
肖宪玲 郑军 刘晓智
肖宪玲 1 郑军 2 刘晓智 3 （1. 天津医科大学中心妇产科临床学院 儿科学系，天 津 300070；2. 天津市中心妇产科医院 新生儿科，天津 300100；3. 天津市第五 中心医院 中心实验室，天津 300450）
Impact of protein small ubiquitin-like modifier modification on neural development and function
XIAO Xian-ling, ZHENG Jun, LIU Xiao-zhi
摘要 小泛素样修饰体（small ubiquitin-like modi?er SUMO）是一类结构及酶联途径与泛素类似但功能 迥异的小分子蛋白。SUMO 在激活酶、结合酶和连 接酶的作用下与底物共价结合，在 SUMO 特异性蛋 白酶（SUMO-speci?c protease，SENPs）作用下与底 物解离。在神经系统发育过程中，蛋白质 SUMO 修饰参与多种生物过程，如转录调控、介导激酶信 号通路、稳定蛋白质、参与突触形成和神经元兴奋 性等，这使得蛋白质 SUMO 化修饰在神经系统发育 以及维持神经功能方面发挥重要作用。
关键词:
小泛素样修饰体 ')" href="#">小泛素样修饰体
突触形成 ')" href="#"> 突触形成
神经退行性疾病')" href="#"> 神经退行性疾病
收稿日期: 2017-12-06
出版日期: 2018-04-30
发布日期: 2018-05-22
期的出版日期: 2018-04-30
通讯作者:
郑军http://www.cnkang.com/yyk/docindex/231294/
刘晓智
E-mail: zhengjun.1964@163.com lxz7997@126.com
引用本文:
肖宪玲 郑军 刘晓智 . 蛋白质小泛素样修饰体化修饰对神经 发育和功能的影响 [J]. 发育医学电子杂志, 2018, 6(2): 117-120.
Impact of protein small ubiquitin-like modifier modification on neural development and function . Journal of Developmental Medicine(Electronic Version), 2018, 6(2): 117-120.
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