助生育技术,低出生体重," /> 助生育技术,低出生体重,"/> ART , Low birth weight,"/> <span style="font-size:14px;line-height:2;">辅助生育技术低出生体重儿</span><span style="font-size:14px;line-height:2;">发生率及其影响因素分析</span><span style="font-size:14px;"></span>
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发育医学电子杂志  2014, Vol. 2 Issue (2): 65-68    
  围产医学   论著 |产科 |
辅助生育技术低出生体重儿发生率及其影响因素分析
国家重大科学研究计划项目《2007cB948104》课题组
Study on the incidence of IOW birth weight in the newborn conceived from ART
Research Group of the National Basic Research Program of China(2007 CB948104)
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摘要 摘要目的考察辅助生育技术(ART)对低出生体重发生率的影响及原因。方法采用回顾性队列研究方法,对浙江大学医学院附属妇产科医院等国内6个生殖中心ART出生儿(ART组)和同地区、同时期配对的自然妊娠出生儿(对照组)的低出生体重(LBW)发生率进行比较和分析。结果共统计分析ART组新生儿12 140例,其中单胎6 499例(53.5%),多胎5 641例(46.5%);对照组新生儿18 800例,单胎18 067例(96.1%),多胎733例(3.9%)。比较表明,虽然总体上ART组的LBW发生率接近于对照组3倍(22.9%比8.5%,P<0.001),但分组分析却显示,比较对照组LBW发生率,无论是单胎『5.1%比6.5%(ART组比对照组,下同),P<0.001],还是多胎(43.3%比
58.3%,P<0.001),或单胎早产(30.o%比53.1%,P<0.001),或多胎足月和多胎早产的ART组LBW发生率(24.4%比35.8%,P<0.001;60.4%比75.7%,P<0.001),实际均呈统计学意义上的显著性下降。结论ART多胎是导致新生儿LBW发生率显著升高的根本原因,ART过程本身可导致新生儿体重增加。
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国家重大科学研究计划项目《cB》课题组
关键词:  助生育技术')" href="#">助生育技术  低出生体重')" href="#">低出生体重    
Abstract: 【Abstract】Objective To investigate the effects and possible causes of ART on the Low birth weight(LBW)of the newborn.Methods Infertility that received fresh IVF/ICSI treatnmnt from six reproductivecenters was included in our study.Naturally conceived pregnancies were selected by computer randomly illatc—hing with age and area.Comparison of the incidences of LBW of the newborn between the group of ART andnaturally control were carried out.Results Totally 12 140 ART newborns and 18 800 naturally conceivednewborns were retrieved.The results showed:(1)The incidence of LBW of ART newborn is higher than thatin the control(22.9%VS 8.5%,P<0.001);(2)The incidences of LBW of the singleton in ART is lowerthan the eontrol(5.1%VS 6.5%.P<0.001).and the sanle incidences of the multiple in ART iS also lowerthan the control(43.3%VS 58.3%,P<0.001);(3)The ratios of LBW in the term singletons is similar(2.O%VS 1.7%,P>0.05),but the incidence of LBW in premature singletons in ART is lower than theeontrol(30.0%VS 53.1%,P<0.001);(4)The rates of LBW in term nmltiple in ART is lower than thecontrol(24.4%VS 35.8%,P<0.001),as well as in premature nmltiple in ART and the control(60.4%VS 75.7%,P<0.001)。Conclusion Multiple pregnancy result in the increased incidence of LBW in thenewborn conceived from ART.Theprocedures of ART itself might lead the growing weight of newborns.
Key words:  ART ')" href="#">ART     Low birth weight
收稿日期:  2014-02-21                出版日期:  2014-04-30      发布日期:  2019-09-05      期的出版日期:  2014-04-30
基金资助: 国家重大科学研究计划项目《2007cB948104》资助
引用本文:    
国家重大科学研究计划项目《cB》课题组. 辅助生育技术低出生体重儿发生率及其影响因素分析[J]. 发育医学电子杂志, 2014, 2(2): 65-68.
Research Group of the National Basic Research Program of China( CB). Study on the incidence of IOW birth weight in the newborn conceived from ART. Journal of Developmental Medicine(Electronic Version), 2014, 2(2): 65-68.
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