发育医学电子杂志 Vol. 2 132-134
临床遗传
专题笔谈
人源化小鼠在人造血免疫系统 研究中的应用
李晓燕 胡正 赵同标
1.中国科学院动物研究所计划生育生殖生物学国家重点实验室，北京 100101；2.吉林大学白求恩第一医院，长春
Humanized mice to study human lymphohematopoietic system
LI Xiao-yan HU Zheng ZHAO Tong-biao
摘要 人源化小鼠模型是指在小鼠体内移植人的细 胞或组织，或者在小鼠体内重组性表达人的某些 基因，用于研究人的生理、病理及发育情况的小 鼠模型。尽管人类的基因组同小鼠等哺乳动物的 同源性很高，但是人类与模式哺乳动物的结构及 生理仍然存在显著的差别，这导致利用动物模型 如小鼠等得到的许多实验结果并不能够解释人体 的生理和病理现象。因此，人源化小鼠模型在研 究人的生理、病理、药理及发育等领域发挥着至 关重要的作用。
关键词:
人源化小鼠模型')" href="#">人源化小鼠模型
免疫缺陷')" href="#">免疫缺陷
造血干细胞
收稿日期: 2014-05-04
出版日期: 2014-07-30
发布日期: 2019-09-05
期的出版日期: 2014-07-30
通讯作者:
胡正http://school.freekaoyan.com/jilin/jlu/daoshi/2016/04-07/1460035961558409.shtml
赵同标https://baike.baidu.com/item/%E8%B5%B5%E5%90%8C%E6%A0%87/10008526
E-mail: Email：zhenghu0108@outlook.com; Email：tbzhao@ioz.ac.cn
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