发育医学电子杂志 Vol. 2 135-138
发育基础
专题笔谈
血液和心血管疾病研究的 重要模式生物——斑马鱼
鲍丙浩 谢尚论 宋彬锋 贾海波
华中科技大学生命科学与技术学院 人类基因组研究中心分子 生物物理教育部重点实验室，武汉 430074
An important model for study on blood and cardiovascular disease ——Zebrafish
BAO Bing-hao, XIE Shang-lun, SONG Bin-feng , et al
摘要 斑马鱼原产于印度东部的恒河流域，因背部 有纵向的蓝白相间条纹而得名。在28 ℃水温时， 24 受精后小时（hpf）斑马鱼主要的脏器原基都基 本形成，脑、心脏和体节等清晰可见。胚胎和幼 鱼身体透明，在显微镜下可直接看到其心脏搏动 和血液循环。3 个月性成熟, 成年鱼体长3 ~ 6 cm。 雄鱼体形细长, 腹部和鳍有金黄色斑点，雌鱼体形 丰满无金黄色斑点。成年鱼产卵量大，一对健康 的斑马鱼一周可产卵300 枚左右。作为较低等的 脊椎动物，斑马鱼架起了以果蝇、线虫为代表的 无脊椎动物（小模式生物）和小鼠为代表的哺乳 动物（大模式生物）之间的桥梁。
关键词:
斑马鱼
白血病干细胞
贫血症
收稿日期: 2013-12-02
出版日期: 2014-07-30
发布日期: 2019-09-05
期的出版日期: 2014-07-30
基金资助: 国家科技部973项目（2013CB945300），自然科学基金（81090414 和31171387）
通讯作者:
贾海波http://life.hust.edu.cn/info/1021/1541.htm
E-mail: haibo.jia@mail.hust.edu.cn
引用本文:
鲍丙浩 谢尚论 宋彬锋 贾海波. 血液和心血管疾病研究的 重要模式生物——斑马鱼 [J]. 发育医学电子杂志, 2014, 2(3): 135-138.
An important model for study on blood and cardiovascular disease ——Zebrafish . Journal of Developmental Medicine(Electronic Version), 2014, 2(3): 135-138.
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