Abstract: 【Abstract】 Objective To study the clinical features of term infants who have patent ductus arteriosus (PDA) and need for surgical ligation. Method Retrospective analyses were performed before and after surgical bedside ligation treatment about the clinical manifestation, laboratory examinations, environmental indicators, inflammatory markers, and biochemical changes on 16 cases of PDA term newborns who required ventilator support and were ibuprofen medications ineffective in the neonatal intensive care. Result All patients had dyspnea, shortness of breath after activities, cyanoderma, three depressions positive, precordial murmur, and lungs moist rales. Liver increased over the ribs 3cm in seven cases of neonatal. 3 cases had edema of both legs. Preoperative chest X-ray radiograph showed an increase of pulmonary blood and, lung markings, as well as patchy shadow. All patients had metabolic acidosis and hypoproteinemia (total protein, albumin, and prealbumin all decreased). The average inside diameter of PDA was 4.244 ± 1.080 mm (2.5mm to 6.0mm). The time of the PDA ligation was 17.938 ± 8.706 days after birth; the average preoperative intubation and mechanical ventilation time was 10.125 ± 6.087 days. Signs and symptoms in postoperative children improved obviously.Pulmonary blood was significantly reduced in lung at 3 days after operation. The average postoperative ventilation was 3.667 ± 2.743 days. Conclusion Bedside ligation closure of PDA is safe and effective for left toright shunt heavier, drugs ineffective, even combined with other cardiac malformations. Surgical closure patentductus arteriosus is a good choice for the treatment of congestive heart failure, to prevent the occurrence of
pulmonary vascular disease, and to short the duration of mechanical ventilation.
2014, Vol. 2 
