发育医学电子杂志  2020, Vol. 8 Issue (4): 378-384 DOI: 10.3969/j.issn.2095-5340.2020.04.019 |
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发育基础
综述
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精原干细胞的自我更新及分化调控的研究现状与展望
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| 罗芳 李朝晖 赵小阳 |
1. 南方医科大学基础医学院 发育生物学教研室，广东 广州 510515；2. 南方医科大学顺德医院 博士后工作站，广东 顺德 528000
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Research and prospect of self-renewal and differentiation regulation for spermatogonial stem cell
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| Luo Fang, Li Zhaohui, Zhao Xiaoyang |
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摘要
精 原 干 细 胞（spermatogonial stem cells，SSCs）是一种可维持雄性生育力的成体干细胞，与其周围的生殖系统体细胞之间形成复杂的相互作用，在睾丸中共同构成了可产生精子的微环境。为了生育能力的长期维持，SSCs 需要在维持自我更新和分化之间进行转换，而这种命运转换与其周围的体细胞形成的微环境密切相关。此外，生殖细胞与体细胞共同构建的微环境处于一个动态的平衡之中，即SSCs 执行自我更新或是启动分化，均与微环境中各类细胞与体细胞的数量相关。因此，本综述主要对SSCs 自我更新与分化启动的分子机制进行论述。
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| 关键词:
精原干细胞')" href="#">
精原干细胞
分子调控
减数分裂启动
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收稿日期: 2020-06-16
发布日期: 2020-11-05
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| 基金资助:
国家自然科学基金青年项目（31700676）；广东省自然科学基金项目（2016A030313604）； 广东省基础与应用基础研究基金项目（2020A1515010877）；中国博士后科学基金（2019M652954）
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通讯作者:
赵小阳
E-mail: zhaoxiaoyang@smu.edu.cn
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