Association study between body mass index and gut microbial diversity among children
Gu Zhuohe, Chen Zanxiong, Dong Guanghui, et al
1. Department of Nutriology, Maternal and Children’s Health Hospital of Maoming, Guangdong, Maoming 525000, China;2. Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department ofOccupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangdong,Guangzhou 510080, China
Abstract: Objective To explore the association between body mass index (BMI) and gut microbial diversity among children. Methods A cross-sectional study was conducted, 87 children with average age (11±2) years were recruited from 1st to 7th July 2018 in Maoming, Guangdong province. According to the child growth reference reported by WHO in 2006, the subjects were separated into four groups: lean, normal, overweight and obesity group. We detected the base sequences in 16S V4-V5 region of gut flora from fecalsamples by Illumina Miseq high-throughput method, and then we performed generalized linear models to assess the relations of BMI and the indexs of gut microbial diversity including of Chao, Ace, Shannon and Simpson index among these children. Results With per 1 kg/m2 increment of BMI in obesity children, Shannon index decreased by 1.31% (95% CI: -2.31%, -0.25%), Simpson index inversely increased by 3.89 %(95% CI: 1.01%, 6.83%). As for lean children, Ace index had the decrement of 4.27% (95%CI: -8.14%, -0.24%). Additionally, trend analysis showed that Shannon index (P=0.042) tend to be decreased with the increase of BMI quartiles. Conclusions BMI is related with gut microbial diversity among children, gut microbial diversity tended to be descended along with increased BMI. Moreover, aforementioned relations may vary by groups.
古灼和 陈赞雄 董光辉 曾晓雯 谢彦奇 李青青. 儿童体重指数与肠道菌群多样性的关联性研究[J]. 发育医学电子杂志, 2021, 9(2): 103-108.
Gu Zhuohe, Chen Zanxiong, Dong Guanghui, et al. Association study between body mass index and gut microbial diversity among children. Journal of Developmental Medicine(Electronic Version), 2021, 9(2): 103-108.
2021, Vol. 9 
